Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes
文献类型： 外文期刊
作者： Zhang, Shuai 1 ; Wang, Ruixue 1 ; Huang, Cheng 1 ; Zhang, Ludan 1 ; Sun, Lin 1 ;
作者机构： 1.Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100193, Peoples R China
关键词： aneuploidy; dosage compensation; inverse dosage effect; transcription factors; inverse regulators
期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）
ISSN：
年卷期： 2021 年 12 卷 10 期
页码：
收录情况： SCI
摘要： Aneuploidy, which disrupts the genetic balance due to partial genome dosage changes, is usually more detrimental than euploidy variation. To investigate the modulation of gene expression in aneuploidy, we analyzed the transcriptome sequencing data of autosomal and sex chromosome trisomy in Drosophila. The results showed that most genes on the varied chromosome (cis) present dosage compensation, while the remainder of the genome (trans) produce widespread inverse dosage effects. Some altered functions and pathways were identified as the common characteristics of aneuploidy, and several possible regulatory genes were screened for an inverse dosage effect. Furthermore, we demonstrated that dosage changes of inverse regulator Inr-a/pcf11 can produce a genome-wide inverse dosage effect. All these findings suggest that the mechanism of genomic imbalance is related to the changes in the stoichiometric relationships of macromolecular complex members that affect the overall function. These studies may deepen the understanding of gene expression regulatory mechanisms.
- 相关文献
作者其他论文 更多>>
-
Identification and characterization of pigeon adenovirus 1 as an emerging pathogen in pigeons from Northern and Northwest China
作者：Yang, Zhiyuan;Zhou, Yuting;Lin, Jian;Huang, Cheng;Yang, Baolin;Duan, Huijuan;Cui, Jian;Zhao, Jicheng;Liu, Yuehuan;Gao, Jie;Luo, Weijue;Cheng, Shuisheng;Wang, Xiuqing;Wang, Guoliang;Liu, Guiming
关键词：Pigeon adenovirus 1; PiAdV-1; Fiber-2; Pigeon; Pathological changes; Viral characterization
-
Circabidian rhythm of sex pheromone reception in a scarab beetle
作者：Wang, Yinliang;Dong, Huanhuan;Qu, Yafei;Qin, Jianhui;Li, Kebin;Cao, Yazhong;Zhang, Shuai;Yin, Jiao;Wang, Yinliang;Dong, Huanhuan;Zhou, Yuxin;Ren, Bingzhong;Luo, Chen;Leal, Walter S.
关键词：
-
Recombinant avian metapneumovirus subtype C expressing HA protein of H9N2 avian influenza virus are stable and induce protection
作者：Guo, Yu;Zhang, Shuai;Zuo, Yuzhu;Liu, Tao;Wang, Yun;Fan, Jinghui;Guo, Yu;Cheng, Jing;Zhang, Yuanyuan;Yang, Chun;Cheng, Chunjie;Jiang, Haijun;Wang, Yun
关键词：avian metapneumonovirus/C; enhance green fluorescent protein; HA protein; immune protection
-
Surface Defect Detection of Cabbage Based on Curvature Features of 3D Point Cloud
作者：Gu, Jin;Zhang, Yawei;Deng, Junwen;Zhang, Bin;Yin, Yanxin;Yin, Yanxin;Wang, Ruixue
关键词：defect detection; cabbage; curvature features; 3D point cloud; depth camera
-
GF-4 Satellite Fire Detection With an Improved Contextual Algorithm
作者：Zhang, Ning;Sun, Lin;Sun, Zhendong
关键词：Reflectivity; Temperature measurement; MODIS; Combustion; Brightness temperature; Monitoring; Detection algorithms; Brightness temperature; fire point identification; GF-4; spatial characteristics; time phase change
-
Influence of dietary phosphorus concentrations on the performance of rearing pigeons (Columba livia), and bone properties of squabs
作者：Ji, Feng;Zhang, Shuai;An, Yong;Shao, Yuxin;Du, Shaohua;Li, Xing;Sun, Xiaoshan;An, Yong;Wang, Zheng;Du, Shaohua;Li, Xing;Sun, Xiaoshan
关键词：phosphorus; breeding pigeon; performance; tibia; squab
-
Surface Defect Detection of Cabbage Based on Curvature Features of 3D Point Cloud
作者：Gu, Jin;Zhang, Yawei;Deng, Junwen;Zhang, Bin;Yin, Yanxin;Yin, Yanxin;Wang, Ruixue
关键词：defect detection; cabbage; curvature features; 3D point cloud; depth camera
