Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila
文献类型： 外文期刊
作者： Zhang, Shuai 1 ; Qi, Haizhu 1 ; Huang, Cheng 1 ; Yuan, Lijia 1 ; Zhang, Ludan 1 ; Wang, Ruixue 1 ; Tian, Yu 1 ; Sun, Lin 1 ;
作者机构： 1.Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100193, Peoples R China
期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.38； 五年影响因子：5.134 ）
ISSN： 2045-2322
年卷期： 2021 年 11 卷 1 期
页码：
收录情况： SCI
摘要： The inverse dosage effect caused by chromosome number variations shows global consequences in genomic imbalance including sexual dimorphism and an X chromosome-specific response. To investigate the relationship of the MSL complex to genomic imbalance, we over-expressed MSL2 in autosomal and sex chromosomal aneuploids, and analyzed the different transcriptomes. Some candidate genes involved in regulatory mechanisms have also been tested during embryogenesis using TSA-FISH. Here we show that the de novo MSL complex assembled on the X chromosomes in females further reduced the global expression level on the basis of 2/3 down-regulation caused by the inverse dosage effect in trisomy through epigenetic modulations rather than induced dosage compensation. Plus, the sexual dimorphism effect in unbalanced genomes was further examined due to the pre-existing of the MSL complex in males. All these results demonstrate the dynamic functions of the MSL complex on global gene expression in different aneuploid genomes.
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