The dynamic N1-methyladenosine RNA methylation provides insights into the tomato fruit ripening
文献类型： 外文期刊
作者： Ma, Lili 1 ; Zuo, Jinhua 1 ; Bai, Chunmei 1 ; Fu, Anzhen 1 ; Wang, Qing 1 ; Zhou, Zhongjing 3 ; Deng, Zhiping 3 ; Tan, Jinjuan 3 ; Bouzayen, Mondher 4 ; Zheng, Yanyan 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Agrifood Proc & Nutr, Beijing Vegetable Res Ctr, Beijing Key Lab Fruits & Vegetable Storage & Proc,, Beijing 100097, Peoples R China
2.Nanjing Forestry Univ, Coll Light Ind & Food Engn, Nanjing 210037, Jiangsu, Peoples R China
3.Zhejiang Acad Agr Sci, Hangzhou 310021, Peoples R China
4.Univ Toulouse, Lab Rech Sci Vegetales Genom & Biotechnol Fruits, CNRS, UPS,UMR5546,Toulouse INP, Toulouse, France
关键词： m(1)A modification; tomato; fruit ripening; mRNA
期刊名称：PLANT JOURNAL （ 影响因子：5.7； 五年影响因子：7.0 ）
ISSN： 0960-7412
年卷期： 2024 年 120 卷 5 期
页码：
收录情况： SCI
摘要： N-1-methyladenosine (m(1)A) methylation is an essential mechanism of gene regulation known to impact several biological processes in living organisms. However, little is known about the abundance, distribution, and functional significance of mRNA m(1)A modification during fruit ripening of tomato the main model species for fleshy fruits. Our study shows that m(1)A modifications are prevalent in tomato mRNA and are detected in lncRNA and circRNA. The distribution of m(1)A peaks in mRNA segments indicates that m(1)A is mainly enriched at the start codon and CDS regions. Assessing changes in global RNA methylation during fruit ripening in wild-type tomatoes and in the ripening-impaired Nr mutant affected in the ethylene receptor gene (SlETR3) revealed a decrease in the overall methylation levels from mature green (MG) stage to 6 days postbreaker (Br + 6). Nr mutant fruits show significantly lower methylation levels than Ailsa Craig (AC) fruits. Notably, differences in m(1)A methylation are well correlated to the expression levels of a number of key ripening-related genes. The integration of RNA-seq and MeRIP-seq data suggests a potential positive impact of m(1)A modifications on gene expression. In comparison to the AC fruits, the hypomethylation and reduced expression of ethylene-related genes, ACO3, EBF1, and ERF.D6, in the Nr mutants likely underpin the distinct phenotypic traits observed between the two fruit genotypes at the Br6 stage. Overall, our study brings further arguments supporting the potential significance of m(1)A methylation modifications in fruit ripening, a developmental process that is instrumental to plant reproduction and to fruit sensory and nutritional qualities.
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