您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Green tea peptides ameliorate diabetic nephropathy by inhibiting the TGF-beta/Smad signaling pathway in mice

文献类型： 外文期刊

作者： Chen, Xuhui 1 ; Sun, Lingli 2 ; Li, Dongli 1 ; Lai, Xingfei 2 ; Wen, Shuai 2 ; Chen, Ruohong 2 ; Zhang, Zhenbiao 2 ; Li, Qiuhua 2 ; Sun, Shili 2 ;

作者机构： 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

2.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Guangzhou 510640, Peoples R China

3.Int Healthcare Innovat Inst Jiangmen, Jiangmen 529040, Peoples R China

期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）

ISSN： 2042-6496

年卷期： 2022 年 13 卷 6 期

页码：

收录情况： SCI

摘要： Diabetic nephropathy (DN) is the most important cause of middle and late-stage chronic kidney disease. Green tea polypeptides are extracted from tea pomace, and exhibit various pharmacological effects. In this study, we analyzed the reno-protective effects of green tea peptides in diabetic db/db mice, and explored the underlying mechanisms. Peptide treatment for 5 weeks significantly reduced the blood glucose levels and other indices of diabetes, and alleviated renal injury measured in terms of blood creatinine, urea nitrogen and urinary albumin/urinary creatinine levels. Mechanistically, the green tea peptides downregulated p-Smad2/3, alpha-SMA, ZO-1 and vimentin proteins in the kidney tissues, and elevated Smad7. Thus, green tea peptides inhibited the deposition of ECM proteins by suppressing excessive activation of the TGF-beta/Smad signaling pathway and reducing fibronectin levels. On the other hand, tea peptides ameliorated renal injury by inhibiting the production of inflammatory factors (iNOS and TNF-alpha) by suppressing the NF-kappa B signaling pathway. In addition, we confirmed the inhibitory effect of green tea peptides on the TGF-beta/Smad signaling pathway in TGF-beta 1-stimulated HK-2 cells. Therefore, tea peptides can be considered as an effective candidate for alleviating DN.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台