The LAMMER Kinase MoKns1 Regulates Growth, Conidiation and Pathogenicity in Magnaporthe oryzae
文献类型： 外文期刊
作者： Li, Lin 1 ; Zhu, Xue-Ming 1 ; Wu, Jia-Qi 2 ; Cao, Na 3 ; Bao, Jian-Dong 1 ; Liu, Xiao-Hong 4 ; Lin, Fu-Cheng 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Managing Biot & Chem Treats Qual &, Hangzhou 310021, Peoples R China
2.Jiliang Univ, Coll Life Sci, Zhejiang Prov Key Lab Biometrol & Inspect & Quara, Hangzhou 310018, Peoples R China
3.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China
4.Zhejiang Univ, Inst Biotechnol, State Key Lab Managing Biot & Chem Treats Qual &, Hangzhou 310058, Peoples R China
关键词： Magnaporthe oryzae; LAMMER kinase; pathogenicity; conidiation
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）
ISSN：
年卷期： 2022 年 23 卷 15 期
页码：
收录情况： SCI
摘要： Magnaporthe oryzae is an important pathogen that causes a devastating disease in rice. It has been reported that the dual-specificity LAMMER kinase is conserved from yeast to animal species and has a variety of functions. However, the functions of the LAMMER kinase have not been reported in M. oryzae. In this study, we identified the unique LAMMER kinase MoKns1 and analyzed its function in M. oryzae. We found that in a MoKNS1 deletion mutant, growth and conidiation were primarily decreased, and pathogenicity was almost completely lost. Furthermore, our results found that MoKns1 is involved in autophagy. The Delta Mokns1 mutant was sensitive to rapamycin, and MoKns1 interacted with the autophagy-related protein MoAtg18. Compared with the wild-type strain 70-15, autophagy was significantly enhanced in the Delta Mokns1 mutant. In addition, we also found that MoKns1 regulated DNA damage stress pathways, and the Delta Mokns1 mutant was more sensitive to hydroxyurea (HU) and methyl methanesulfonate (MMS) compared to the wild-type strain 70-15. The expression of genes related to DNA damage stress pathways in the Delta Mokns1 mutant was significantly different from that in the wild-type strain. Our results demonstrate that MoKns1 is an important pathogenic factor in M. oryzae involved in regulating autophagy and DNA damage response pathways, thus affecting virulence. This research on M. oryzae pathogenesis lays a foundation for the prevention and control of M. oryzae.
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