BAFF enhances B-cell-mediated immune response and vaccine-protection against a very virulent IBDV in chickens
文献类型： 外文期刊
作者： Chen, Long 1 ; Ran, Mao Ju 4 ; Shan, Xiao Xiao 1 ; Cao, Meng 1 ; Cao, Peng 1 ; Yang, Xiao Man 1 ; Zhang, Shuang Quan 1 ;
作者机构： 1.Nanjing Normal Univ, Coll Life Sci, Nanjing 210046, Peoples R China
2.Jiangsu Prov Key Lab Mol & Med Biotechnol, Nanjing 210046, Peoples R China
3.Jiangsu Engn Res Ctr Biomed Funct Mat, Nanjing 210097, Peoples R China
4.Jiangsu Ac
期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）
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收录情况： SCI
摘要： Infectious bursal disease (IBD) is an acute, highly infectious and immunosuppressive disease caused by IBDV, which specifically targets destruction of B cells in the bursa of Fabricius. B-cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important factor for B-cell proliferation and survival. Here we demonstrate that human soluble BAFF (hsBAFF) may enhance humoral immune response by elevating B lymphocyte activity of secretion of immunoglobulin (Ig) such as IgA, IgM and IgG in chickens immunized or unimmunized with an inactivated IBDV vaccine from a very virulent strain. Of importance, we found that hsBAFF, as a co-immunostimulant for vaccination, may play a vital role in amplifying the specific protective immune response, thereby potently preventing very virulent IBDV challenge. This is supported by serological evidence that hsBAFF may effectively enhance higher specific IgG activity and titre in serum of immunized chickens. The findings strongly suggest that BAFF may be exploited in combination with specific vaccination for prevention of IBD.
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