文献类型： 外文期刊

作者： Rubel, Rosalia ¹ ; Dalla Santa, Herta Stutz ¹ ; Fernandes, Luiz Claudio ³ ; Cavalcante Lima Filho, Jose Herme ¹ ;

作者机构： 1.Univ Fed Parana, Dept Engn Quim, Div Engn Bioproc & Biotecnol Ind, BR-81531970 Curitiba, Parana, Brazil

2.Unictr, Dept Food Engn, Guarapuava, Parana, Brazil

3.Univ Fed Parana, Dept Physiol, BR-81531970 Curitiba, Parana, Brazil

4.Univ Fed Parana, Dept Med Pathol, BR-81531970 Curitiba, Parana, Brazil

5.Univ Fed Parana, Dept Pediat, BR-81531970 Curitiba, Parana, Brazil

6.Univ Fed Parana, Dept Biol Sci, BR-81531970 Curitiba, Parana, Brazil

7.Univ Catholic Parana, Biol Course, Curitiba, Parana, Brazil

8.Zhejiang Acad Agr Sci, Inst Hort, Hangzhou, Peoples R China

关键词： Immune System: Chemical Coordination and Homeostasis;MC - Pharmacognosy: Pharmacology;MC - Tumor Biology

期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.921； 五年影响因子：1.879 ）

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收录情况： SCI

摘要： This study evaluated the immunomodulatory and antitumor effects of a diet supplemented with Ganoderma lucidum (Ling Zhi or Reishi) medicinal mushroom mycelium obtained by solid-state fermentation. Over 14 weeks, animals from a test group were fed with 2 concentrations of G. lucidum mycelium, at 85% or 50%, labeled G85 and G50 diets, respectively. A control group received a regular diet. In the tenth week, half the animals from the test group and half the animals from the control group were inoculated with a suspension of Sarcoma 180 cells. Saline was injected in the remaining animals. In week 14, plasma levels of cytokines and the population of CD3(+), CD4(+), CD8(+), CD19(+), and CD16(+)/CD32(+) cells were evaluated. When compared to the control group, G. lucidum-supplemented diets altered the immune systems of the mice significantly (p < 0.05) the G50 diet proving more effective than the G85 diet. Mice inoculated with saline and fed with the G50 diet presented an increase in CD19(+) and CD16(+)/CD32(+) cell populations, along with an elevation in the tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma concentrations. Conversely, tumor-bearing mice fed with the G50 diet (labeled the G50-S group) presented an increase in CD3(+), CD4(+), and CD8(+) cells, but a decrease in CD19(+) and CD16(+)/CD32(+) cell populations. TNF-alpha and IFN-gamma concentrations were reduced in the G50-S group. The G50-S group presented a tumor weight 84% lower than that found in the control group. These results suggest that the immunomodulatory effect provoked by the consumption of G. lucidum mycelium possibly increased mice resistance against Sarcoma 180.