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Leptin stimulates hepatic activation of thyroid hormones and promotes early posthatch growth in the chicken

文献类型： 外文期刊

作者： Li, Rongjie 1 ; Hu, Yan 1 ; Ni, Yingdong 1 ; Xia, Dong 2 ; Grossmann, Roland 4 ; Zhao, Ruqian 1 ;

作者机构： 1.Nanjing Agr Univ, Key Lab Anim Physiol & Biochem, Nanjing 210095, Peoples R China

2.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China

3.Inst Poultry Sci Jiangsu Prov, Key Lab Poultry Hered & Breeding, Yangzhou 225003, Jiangsu, Peoples R China

4.Inst Anim Sci Mariensee, Dept Funct Genom & Bioregulat, D-31535 Neustadt, Germany

关键词： Chicken;GHR;Hepatocytes;IGF-I;Iodothyronine deiodinases;Leptin

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY （ 影响因子：2.32； 五年影响因子：2.465 ）

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收录情况： SCI

摘要： Hepatic iodothyronine deiodinases (Ds) are involved in the conversion of thyroid hormones (THs) which interacts with growth hormone (GH) to regulate posthatch growth in the chicken. Previous studies suggest that leptin-like immunoreactive substance deposited in the egg may serve as a maternal signal to program posthatch growth. To test the hypothesis that maternal leptin may affect early posthatch growth through modifying hepatic activation of THs, we injected 5.0 μg of recombinant murine leptin into the albumen of breeder eggs before incubation. Furthermore, chicken embryo hepatocytes (CEHs) were treated with leptin in vitro to reveal the direct effect of leptin on expression and activity of Ds. In ovo leptin administration markedly accelerated early posthatch growth, elevated serum levels of total and free triiodothyronine (tT3 and fT3), while that of total thyroxin (tT4) remained unchanged. Hepatic mRNA expression and activity of D1 which converts T4 to T3 or rT3 to T2, were significantly increased in leptin-treated chickens, while those of D3 which converts T3 to T2 or T4 to rT3, were significantly decreased. Moreover, hepatic expression of GHR and IGF-I mRNA was all up-regulated in leptin-treated chickens. Males demonstrated more pronounced responses. A direct effect of leptin on Ds was shown in CEHs cultured in vitro. Expression and activity of D1 were increased, whereas those of D3 were decreased, in leptin-treated cells. These data suggest that in ovo leptin administration improves early posthatch growth, in a gender-specific fashion, probably through improving hepatic activation of THs and up-regulating hepatic expression of GHR and IGF-I.

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