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Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities

文献类型: 外文期刊

作者: Zhou, Xuefeng 1 ; Lu, Yanan 2 ; Lin, Xiuping 1 ; Yang, Bin 1 ; Yang, Xianwen 1 ; Liu, Yonghong 1 ;

作者机构: 1.Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China

2.Chinese Acad Fisheries Sci, E China Sea Fisheries Res Inst, Minist Ag

关键词: Anti-acetylcholinesterase;Brominated aliphatic hydrocarbons;Mutafuran H;Sterols;Toxicity;Xestospongia testudinaria

期刊名称:CHEMISTRY AND PHYSICS OF LIPIDS ( 影响因子:3.329; 五年影响因子:3.4 )

ISSN:

年卷期:

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收录情况: SCI

摘要: Four brominated aliphatic hydrocarbons (1-4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5-9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR (~1H, ~(13)C NMR, HSQC, HMBC, ~1H-~1H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1-4, and 6-9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity.

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