Tissue-specific accumulation of cadmium and its effects on antioxidative responses in Japanese flounder juveniles
文献类型: 外文期刊
作者: Cao, Liang 1 ; Huang, Wei 1 ; Shan, Xiujuan 1 ; Ye, Zhenjiang 4 ; Dou, Shuozeng 1 ;
作者机构: 1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.State Ocean Adm, Lab Marine Ecosyst & Biogeochem, Inst Oceanog 2, Hangzhou 310012, Zhejiang, Peoples R China
3.Chinese Acad Fishery Sci, Yellow Sea Fishery Res Inst, Qingdao 266071, Peoples R China
4.Ocean Univ China, Fishery Coll, Qingdao 266003, Peoples R China
关键词: Accumulation;Antioxidants;Cd;Japanese flounder;LPO
期刊名称:ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY ( 影响因子:4.86; 五年影响因子:4.462 )
ISSN:
年卷期:
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收录情况: SCI
摘要: This study investigated the accumulation of cadmium (0-8mgCdL -1) and its toxicological effects on oxidative stress biomarkers in different tissues of Japanese flounder juveniles. Following Cd exposure for 28d, accumulation of Cd in fish was dose-dependent and tissue-specific, with the greatest accumulation in the liver, followed by the kidney, gill, and muscle. Although the gill and liver mounted active antioxidant responses at ≥4mgL -1Cd including a decrease in glutathione level and GST and GPx activities, the antioxidant response failed to prevent lipid peroxidation induction in these organs. In the kidney, increased GPx and GST activities and decreased SOD activity were observed in fish exposed to high Cd concentrations, but LPO levels did not significantly differ among the exposure concentrations. The gill was most sensitive to oxidative damage, followed by the liver; the kidney was the least affected tissue.
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