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Protective effect of Salvia Miltiorrhizae injection on N(G)-nitro-d-arginine induced nitric oxide deficient and oxidative damage in rat kidney

文献类型： 外文期刊

作者： You, Zhenqiang 1 ; Xin, Yanfei 1 ; Liu, Yan 2 ; Han, Bin 1 ; Zhang, Lijiang 1 ; Chen, Ying 1 ; Chen, Yunxiang 1 ; Gu, Liq 1 ;

作者机构： 1.Zhejiang Acad Med Sci, State Key Lab Safety Evaluat New Drugs, Hangzhou 310013, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Sericulturcd Res Inst, Hangzhou, Zheji

关键词： Kidney damage;N(G)-nitro-d-arginine (d-NNA);Nitric oxide (NO);Oxidative damage;Salvia miltiorrhiza (SM)

期刊名称：EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY （ 影响因子：2.023； 五年影响因子：2.148 ）

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收录情况： SCI

摘要： N(G)-nitro-d-arginine (d-NNA) could convert into N(G)-nitro-l-arginine (l-NNA) in vivo, and kidney is the major target organ. In the chiral inversion process, a number of reactive oxygen species (ROS) were generated and NOS activity was inhibited, which may cause renal damage. Salvia miltiorrhiza (SM), a traditional Chinese drug, was used in the treatment of cardiovascular diseases and chronic renal failure. The aim of the present study was to investigate the kidney damage caused by d-NNA administration for 12 weeks and to evaluate the effects of treatment with SM on d-NNA-induced kidney damage. The rats, induced with d-NNA for period of 12 weeks, showed significant elevation of Blood Urea Nitrogen (BUN), Creatinine (Crea) and MDA levels, and significant decrease of SOD and GSH-Px activities, as compared with control group. In addition, the kidney of rats induced with d-NNA only showed remarkable histopathology, including severe mononuclear cell infiltration, mild tubular dilatation and congestion, and moderate interstitial desmoplasia. After 4 weeks SM treatment, the activity of SOD, GSH-Px and iNOS and the production of NO were significantly higher (P< 0.05), and the levels of BUN, Crea and MDA were significantly lower than that of d-NNA only group (P< 0.05). In addition, treatment with SM showed histopathological protection in tubular dilatation, congestion, mononuclear cell infiltration and interstitial desmoplasia. The present results indicate that the toxicity of d-NNA relates to its ability to generate oxidative stress and upregulate NOS activity in rat kidney. SM probably ameliorates d-NNA-induced nephrotoxicity in rats according to scavenging free radical and upregulating NOS activity.

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