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Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet

文献类型： 外文期刊

作者： Wei, Yuxi 1 ; Xu, Chuanjin 2 ; Liu, Qi 3 ; Xiao, Huihui 1 ; Zhao, Aiyun 1 ; Hu, Yingfen 1 ; Liu, Lei 1 ; Zhao, Ling 1 ;

作者机构： 1.Qingdao Univ, Dept Biol, Qingdao 266071, Peoples R China

2.Qingdao Univ, Sch Med, Affiliated Hosp, Qingdao 266003, Peoples R China

3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

关键词： 1ow density lipoprotein receptor;3-hydroxy-3-methylglutaryl-coenzyme A;hypocholesterolemic activity;phlorotannins;Sargassum thunbergii

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

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收录情况： SCI

摘要： On the basis of activity screening on blood lipid regulation by animal study, we chose high molecular weight phlorotannins from Sargassum thunbergii (HMPs) as a drug to explore the regulating mechanism. The results showed that HMPs could significantly decrease TC and TG levels (p<0.05), and very significantly decrease LDL-C level (p<0.01). Results of a hypocholesterolemic mechanism study showed that HMPs could obviously increase liver LDL-R level (p<0.05), but the fact that they failed to block the synthesis of HMG-CoA reductase excludes a relevant influence on cellular cholesterol biosynthesis. We propose that HMPs from Sargassum thunbergii have a profound hypocholesterolemic effect and the mechanism relies mainly on the increase of LDL-R level in liver.

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