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Inhibitory effect of antioxidant peptides derived from Pinctada fucata protein on ultraviolet-induced photoaging in mice

文献类型： 外文期刊

作者： Wu, Yanyan 1 ; Tian, Qian 1 ; Li, Laihao 1 ; Khan, Muhammad Naseem 2 ; Yang, Xianqing 1 ; Zhang, Zhongmin 3 ; Hu, Xiao 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Minist Agr, Key Lab Aquat Prod Proc, Guangzhou 510300, Guangdong, Peoples R China

2.Ocean Univ China, Coll Food Sci & Engn, Qingdao 266003, Peoples R China

3.Guangzho

关键词： Pinctada fucata;Antioxidant peptides;Anti-photoaging;Biochemical estimation;Histo-pathological

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The superposition of ultraviolet radiation induced (photodamage) aging process is photoaging. Antioxidant peptides derived from Pinctada fucata protein as raw materials were smeared the back of light-aging. The effect of antioxidant peptides on wrinkle generating, skin restoration capacity after pulled up and measure the active of the superoxide dismutase (SOD), catalase (CAT), hydroxyproline, and glutathione peroxidase (GSH-Px) and lipid peroxidation by kit and histological examination of UVB-irradiated skin that the mitotic index of basal cells, the thickness ratio of the epidermis and dermis, fibroblast count, density of collagen fibers and volume density of dermal microvasculature were studied. The result showed that antioxidant peptides had slowed down the progress of wrinkles formation and skin elasticity deceasing induced by acute irradiation of UVB. It also significantly controlled the speed of lipid peroxidation and the reduction of the activity of SOD, GSH-Px, hydroxyprodline and CAT. Histopathological studies showed that the derived antioxidant peptides could reduce the thickness ratio of the dermis and epidermis and increase the mitotic index of basal cells, fibroblast count, density of collagen fibers and volume density of dermal microvascular, these outcomes confirmed the protective role of antioxidant peptides in the process of photoaging

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