Effects of norfloxacin on the drug metabolism enzymes of two sturgeon species (Acipenser schrencki and Acipenser ruthenus)
文献类型： 外文期刊
作者： Li, S. W. 1 ; Wang, D. 1 ; Liu, H. B. 1 ; Lu, T. Y. 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin 150070, Peoples R China
期刊名称：JOURNAL OF APPLIED ICHTHYOLOGY （ 影响因子：0.892； 五年影响因子：0.956 ）
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收录情况： SCI
摘要： The enzyme activities of 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST), and on glutathione (GSH) content, involved in metabolism of the antibiotic Norfloxacin (NFLX), were investigated in Acipenser schrencki and Acipenser ruthenus. Sturgeons weighing 45-55g were kept in an aquarium (0.5mx0.5mx0.9m) for two weeks under controlled conditions (fish density 88 individuals per m(3), 18 degrees C) before the experiment. The two species of sturgeon were divided into five groups each (n=15 in each group), with each group subdivided into three replicates of five fish per tank. A control group in which distilled water was administered orally was also tested. NFLX was forced into the stomachs of the fish at a concentration of 20, 40, 60, 80 and 100mgkg(-1) body weight, respectively. ECOD activities in liver microsomes, and GST activity and GSH content in liver microsomes and blood plasma, were measured and compared. Results indicate that ECOD activity is progressively inhibited with increasing NFLX concentrations. ECOD activity varied from 0.12nmol mg(-1)min(-1) to 0.07nmolmg(-1)min(-1), demonstrating an inhibition rate of 60.83% in A.schrencki and 65.14% in A.ruthenus. In both species tested, GST and GSH levels exhibited a trend of first increasing, and then decreasing with increasing NFLX levels, reaching a peak value at 40mg per kg(-1) body weight. Thus, the presented results indicate that NFLX can induce a change in the activity of some drug metabolism related enzymes such as ECOD and GST in vivo.
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