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The regulatory peptide pidotimod facilitates M2 macrophage polarization and its function

文献类型： 外文期刊

作者： Hu, Shenglan 1 ; Fu, Xudong 2 ; Fu, Aikun 1 ; Du, Wei 1 ; Ji, Jian 3 ; Li, Weifen 1 ;

作者机构： 1.Zhejiang Univ, Key Lab Anim Mol Nutr, Educ Minist, Coll Anim Sci, Hangzhou 310003, Zhejiang, Peoples R China

2.Peoples Hosp Liaocheng, Dept Endocrinol, Liaocheng, Shandong, Peoples R China

3.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou, Guangdong, Peoples R China

关键词： Pidotimod;M2 macrophage;Polarization;Cell migration;Wound healing

期刊名称：AMINO ACIDS （ 影响因子：3.52； 五年影响因子：3.6 ）

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收录情况： SCI

摘要： Pidotimod is a synthetic dipeptide with biological and immunological activity in innate immune responses. It has been reported that pidotimod could promote functional maturation of dendritic cells, but little is known about the regulation of macrophages. Recent studies have demonstrated that Ml or M2 polarized macrophages are of great importance for responses to microorganism infection or host mediators. The aim of this study was to determine the effectiveness of pidotimod on mouse bone marrow-derived macrophage polarization and its function. The results showed that pidotimod had no influence on M1-polarized macrophage. While interestingly, a significant increase of M2 marker gene expression (Arg1, Fizz1, Ym1, MR) was observed (p < 0.01) in IL-4-induced M2 macrophage treated with pidotimod. In addition, cell surface expression of mannose receptor was dramatically enhanced using fluorescence activated cell sorter (FACS) analysis. Furthermore, the function of M2 macrophage was also determinated. The results showed that the supernatant of pidotimod-treated M2 macrophage could increase the migration (p < 0.05) and enhance the wound closure rate (p < 0.05) of MLE-12 cells. Collectively, it could be concluded that pidotimod significantly facilitated IL-4-induced M2 macrophage polarization and improves its function.

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