文献类型： 外文期刊

作者： Ge, Hui-Lin ¹ ; Liu, Shu-Shen ¹ ; Su, Bing-Xia ² ; Qin, Li-Tang ³ ;

作者机构： 1.Tongji Univ, Coll Environm Sci & Engn, Minist Educ, Key Lab Yangtze Aquat Environm, Shanghai 200092, Peoples R China

2.Chinese Acad Trop Agr Sci, Hainan Prov Key Lab Qual & Safety Trop Fruits & V, Anal & Testing Ctr, Haikou 571101, Peoples R China

3.Guilin Univ Technol, Coll Environm Sci & Engn, Guilin 541004, Peoples R China

关键词： Synergism;Concentration addition;Independent action;ICIM model;Uniform design

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

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收录情况： SCI

摘要： Results from three mathematical approaches to predict the toxicity of uniform design mixtures of four heavy metals (HMs) including Cd(Ⅱ), Ni(Ⅱ), Cu(Ⅱ), and Zn(Ⅱ) and six ionic liquids (ILs) were compared to the observed toxicity of these mixtures on Vibrio qinghaiensis sp.-Q67. Single toxicity analysis indicated that the ILs had greater toxicity than the HMs. Combined toxicities of HMs and ILs were found to be synergistic. The combined toxicities were underestimated by concentration addition (CA) and independent action (IA) models. However, the mixture toxicities were effectively predicted by the integrated CA with IA based on multiple linear regression model (ICIM). We propose that ICIM model can serve as a useful tool for predicting the toxicity of interactive mixtures.