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Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase

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文献类型：外文期刊

作者： Ge, Hui-Lin ¹ ; Liu, Shu-Shen ² ; Su, Bing-Xia ¹ ; Zhu, Xiang-Wei ³ ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Prov Key Lab Qual & Safety Trop Fruits & V, Anal & Testing Ctr, Haikou 571101, Peoples R China

2.Tongji Univ, Coll Environm Sci & Engn, Key Lab Yangtze Aquat Environm, Minist Educ, Shanghai 200092, Peoples R China

3.Qingdao Agr Univ, Coll Resource & Environm, Qingdao 266109, Peoples R China

关键词： ionic liquids;luciferase;molecular level;joint toxicity;concentration addition;independent action;two-stage prediction;NOEC;mixture risk assessment

期刊名称：MOLECULES （影响因子：4.411；五年影响因子：4.587 ）

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收录情况： SCI

摘要： The predicted toxicity of mixtures of imidazolium and pyridinium ionic liquids (ILs) in the ratios of their EC_(50), EC10, and NOEC (no observed effect concentration) were compared to the observed toxicity of these mixtures on luciferase. The toxicities of EC_(50) ratio mixture can be effectively predicted by two-stage prediction (TSP) method, but were overestimated by the concentration addition (CA) model and underestimated by the independent action (IA) model. The toxicities of EC10 ratio mixtures can be basically predicted by TSP and CA, but were underestimated by IA. The toxicities of NOEC ratio mixtures can be predicted by TSP and CA in a certain concentration range, but were underestimated by IA. Our results support the use of TSP as a default approach for predicting the combined effect of different types of ILs at the molecular level. In addition, mixtures of ILs mixed at NOEC and EC10 could cause significant effects of 64.1% and 97.7%, respectively. Therefore, we should pay high attention to the combined effects in mixture risk assessment.

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