您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88

文献类型： 外文期刊

作者： Yang, K. M. 1 ; Jiang, Z. Y. 2 ; Zheng, C. T. 2 ; Wang, L. 2 ; Yang, X. F. 2 ;

作者机构： 1.Sun Yat Sen Univ, Coll Life Sci, Guangzhou 510275, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Key Lab Anim Nutr & Feed South China, Minist Agr,State Key Lab Livestock & Poultry Bree, Guangdong Publ Lab Anim Breeding & Nutr,Inst Anim, Guangzhou 510640, Guangdong, Peoples R China

关键词： diarrhea;enterotoxigenic Escherichia coli K88;intestinal barrier function;Lactobacillus;plantarum young piglets

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：3.159； 五年影响因子：2.912 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The present study was performed to investigate the preventative effect of Lactobacillus plantarum on diarrhea in relation to intestinal barrier function in young piglets challenged with enterotoxigenic Escherichia coli (ETEC) K88. Seventy-two male piglets (4 d old) were assigned to 2 diets (antibiotic-free basal diet with or without L. plantarum, 5 x 10(10) cfu/kg diet) and subsequently challenged or not with ETEC K88 (1 x 10(8) cfu per pig) on d 15 in a 2 x 2 factorial arrangement of treatments. Feed intake and BW were measured on d 15 and 18 (3 d after challenge) for determination of growth performance. On d 18, 1 piglet from each pen was slaughtered to evaluate small intestinal morphology and expression of tight junction proteins at the mRNA and protein levels while another piglet was used for the intestinal permeability test. Before and after ETEC K88 challenge, piglets fed L. plantarum had greater BW, ADG, and ADFI (P < 0.05) and marginally greater G: F (P < 0.10) compared to piglets fed the unsupplemented diet. After ETEC K88 challenge, the challenged piglets did not show an impaired growth performance but had greater incidence of diarrhea compared to the nonchallenged piglets. There was an interaction between dietary L. plantarum and ETEC K88 challenge (P < 0.05) as L. plantarum prevented the ETEC K88-induced diarrhea. Piglets challenged with ETEC K88 also had greater urinary lactulose: mannitol and plasma concentration of endotoxin, shorter villi, deeper crypt depth, and reduced villous height: crypt depth in the duodenum and jejunum and decreased zonula occludens-1 mRNA and occludin mRNA and protein expression in the jejunum (P < 0.05). These deleterious effects caused by ETEC K88 were inhibited by feeding L. plantarum (P < 0.05). There were no effects of either treatment on the morphology and expression of tight junction proteins in ileum. In conclusion, L. plantarum, given to piglets in early life, improved performance and effectively prevented the diarrhea in young piglets induced by ETEC K88 challenge by improving function of the intestinal barrier by protecting intestinal morphology and intestinal permeability and the expression of genes for tight junction proteins (zonula occludens-1 and occludin).

  • 相关文献

[1]Differential expression of intestinal ion transporters and water channel aquaporins in young piglets challenged with enterotoxigenic Escherichia coli K88. Zhu, C.,Ye, J. L.,Yang, J.,Chen, Z.,Liang, R.,Wu, X. J.,Jiang, Z. Y.,Yang, K. M.,Wang, L.,Jiang, Z. Y.. 2017

[2]Dietary soy isoflavone attenuated growth performance and intestinal barrier functions in weaned piglets challenged with lipopolysaccharide. Zhu, Cui,Jiang, Zongyong,Zheng, Chuntian,Wang, Li,Yang, Xuefen,Ma, Xianyong,Gao, Kaiguo,Hu, Youjun,Zhu, Cui,Wu, Yunpeng. 2015

[3]Protective effects of Lactobacillus plantarum on epithelial barrier disruption caused by enterotoxigenic Escherichia coli in intestinal porcine epithelial cells. Wu, Yunpeng,Wu, Yunpeng,Zhu, Cui,Chen, Zhuang,Chen, Zhongjian,Zhang, Weina,Jiang, Zongyong,Ma, Xianyong,Wang, Li,Yang, Xuefen,Jiang, Zongyong.

[4]Comparative epidemiology of porcine circovirus type 3 in pigs with different clinical presentations. Zhai, Shao-Lun,Chen, Qin-Ling,Wei, Wen-Kang,Lv, Dian-Hong,Wen, Xiao-Hui,Zhai, Shao-Lun,Liu, Runxia,Li, Feng,Wang, Dan,Zhai, Shao-Lun,Liu, Runxia,Li, Feng,Zhou, Xia,Zhang, He,Hause, Ben M.,Lin, Tao. 2017

[5]Effects of mulberry (Morus alba L.) leaf polysaccharides on growth performance, diarrhea, blood parameters, and gut microbiota of early-weanling pigs. Zhao, Xiangjie,Li, Lin,Zhao, Xiangjie,Luo, Qiulan,Ye, Mingqiang,Luo, Guoqing,Kuang, Zheshi.

[6]Dietary Zinc Oxide Modulates Antioxidant Capacity, Small Intestine Development, and Jejunal Gene Expression in Weaned Piglets. Zhu, Cui,Lv, Hang,Wang, Li,Jiang, Zongyong,Zhu, Cui,Lv, Hang,Chen, Zhuang,Wu, Xiuju,Chen, Zhongjian,Zhang, Weina,Liang, Rui,Jiang, Zongyong.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台