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Molecular characterization, transcriptional regulation and association analysis with carcass traits of porcine TCAP gene

文献类型： 外文期刊

作者： Qiao, Mu 1 ; Huang, Jingshu 2 ; Wu, Huayu 1 ; Wu, Junjing 1 ; Peng, Xianwen 1 ; Mei, Shuqi 1 ;

作者机构： 1.Hubei Acad Agr Sci, Hubei Key Lab Anim Embryo Engn & Mol Breeding, Inst Anim Husb & Vet, Wuhan 430064, Peoples R China

2.Anim Husb & Vet Bur Hubei Prov, Wuhan 430064, Peoples R China

关键词： Pig;Promoter;SNP;TCAP;Transcriptional analysis

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

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收录情况： SCI

摘要： TCAP (also known as titin-cap or telethonin) is one of the titin interacting Z-disk proteins involved in the regulation and development of normal sarcomeric structure. In this study, we cloned the cDNA and promoter sequences of porcine TCAP gene, which contained a 504. bp full-length coding region. Quantitative real-time PCR (qRT-PCR) analyses showed that porcine TCAP was highly expressed in the skeletal muscle, heart, and kidney. During postnatal muscle development, TCAP expression was down-regulated from 30. days to 120. days in Large White and Meishan pigs. One single nucleotide polymorphism c.334G>A in exon 2 of the TCAP gene was identified and detected by allele-specific primer-polymerase chain reaction (ASP-PCR). Association analysis revealed that the polymorphism had significant associations (P<. 0.05 and P<. 0.01) with some carcass traits. Analysis of the porcine TCAP promoter in different cell lines demonstrated that it is a muscle-specific promoter. In addition, we found that the porcine TCAP promoter can be activated by MyoD, MyoG and MEF2 in myotubes, which indicated that TCAP may play a role in the regulation of porcine skeletal muscle development. These findings provide useful information for the further investigation of the function of TCAP in porcine skeletal muscle.

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