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Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

文献类型： 外文期刊

作者： Huang, Sheng-Zhuo 1 ; Zhang, Xuan 3 ; Ma, Qing-Yun 1 ; Peng, Hua 2 ; Zheng, Yong-Tang; Hu, Jiang-Miao 2 ; Dai, Hao- 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China

2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

3.Chinese Acad

关键词： Excoecaria acerifolia;Euphorbiaceae;Excoecafolin;Anti-HIV-1;Chemotaxonomy

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN：

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收录情况： SCI

摘要： Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerzfolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 mu M, SI >1,836.9,431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.

  • 相关文献

[1]Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia. Huang, Sheng-Zhuo,Ma, Qing-Yun,Dai, Hao-Fu,Zhao, You-Xing,Xu, Feng-Qing,Peng, Hua,Zhou, Jun,Zhang, Xuan,Zheng, Yong-Tang,Huang, Sheng-Zhuo,Ma, Qing-Yun,Dai, Hao-Fu,Zhao, You-Xing.

[2]Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.. Huang, Sheng Zhuo,Kong, Ling Mei,Jiang, He Zhong,Liu, Yu Qing,Hu, Jiang Miao,Li, Yan,Zhou, Jun,Zhao, You Xing,Ma, Qing Yun,Zhao, You Xing,Zhang, Xing Jie,Li, Xing Yao,Zheng, Yong Tang,Huang, Sheng Zhuo,Zhang, Xing Jie,Li, Xing Yao,Kong, Ling Mei,Jiang, He Zhong.

[3]Three new isopimarane diterpenoids from Excoecaria acerifolia. Huang, Sheng-Zhuo,Ma, Qing-Yun,Dai, Hao-Fu,Zhao, You-Xing,Fang, Wei-Wei,Xu, Feng-Qing,Peng, Hua,Zhou, Jun.

[4]Two new terpenoids from the stems of Manihot esculenta. Zeng, Yan-Bo,Li, Shan-Shan,Mei, Wen-Li,Dong, Wen-Hua,Dai, Hao-Fu,Li, Kai-Mian. 2015

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[6]Structure Conservation and Differential Expression of Farnesyl Diphosphate Synthase Genes in Euphorbiaceous Plants. Guo, Dong,Li, Hui-Liang,Peng, Shi-Qing. 2015

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[9]Three new terpenoids from Trigonostemon xyphophylloides (Croiz.) LK Dai and TL Wu. Yu, Li,Zuo, Wen-jian,Mei, Wen-li,Guo, Zhi-kai,Li, Xiao-na,Dai, Hao-fu,Zuo, Wen-jian,Mei, Wen-li,Guo, Zhi-kai,Li, Xiao-na,Dai, Hao-fu,Yu, Li.

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