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Characterization of E3 ubiquitin ligase neuregulin receptor degradation protein-1 (Nrdp1) in the large yellow croaker (Larimichthys crocea) and its immune responses to Cryptocaryon irritans

文献类型： 外文期刊

作者： Zhang, Dong Ling 1 ; Han, Fang 1 ; Yu, Da Hui 2 ; Xiao, Shi Jun 1 ; Li, Ming Yun 3 ; Chen, Jian 1 ; Wang, Zhi Yong 1 ;

作者机构： 1.Jimei Univ, Coll Fisheries, Minist Agr, Key Lab Hlth Mariculture East China Sea, Xiamen 361021, Fujian Province, Peoples R China

2.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Minist Agr, Guangzhou 510300, Guangdong, Peoples R China

3.Ningbo Univ, Coll Ocean, Ningbo 315211, Zhejiang, Peoples R China

关键词： Nrdp1;Larimichthys crocea;Cryptocaryon irritans;Immune response

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN：

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收录情况： SCI

摘要： Neuregulin receptor degradation protein-1 (Nrdp1) was recently identified in humans as an important immune factor responding to the challenge of virus, LPS or cytokine. Its role in fish immune defense and whether it is involved in anti-parasite immunity have not been proven yet. In this report, the full-length cDNA sequence and genomic structure of Nrdp1 in the large yellow croaker Larimichthys crocea (LcNrdp1) were identified and characterized. The full-length cDNA of LcNrdp1 was 1248 bp, including a 5' untranslated region (UTR) of 32 bp, a 3' UTR of 259 bp and an open reading frame (ORF) of 937 bp, encoding a polypeptide of 318 amino acid residues. The full-length genomic DNA sequence of LcNrdp1 was composed of 2635 nucleotides, including four exons and three introns. The putative LcNrdp1 protein had no signal peptide sequence and contained a characteristic Nrdp1 consensus motif C3HC3D ring finger and a Coiled-coil domain. Phylogenetic analysis showed that Nrdpl in fish was closer with that in other vertebrates (79%-90% amino acid identity) than in invertebrates and bacteria (27%-65%). In fishes, Nrdpl in large yellow croaker was closer with that in Takifugu rubripes. The expression profile showed that LcNrdp1 was constitutively expressed in all tested tissues, especially highly expressed in brain, muscle and kidney. Post-infection (PI) with Cryptocaryon irritans, an increased expression of LcNrdp1 was induced in infection sites (skin and gill), whereas in immune organs, the expression of LcNrdp1 was up-regulated in spleen (except the 1st d and 10th d PI) but suppressed in head kidney. These results suggested that LcNrdp1 might play an important immune role in the finfish L crocea in the defense against the parasite C. irritans. (C) 2014 Elsevier B.V. All rights reserved.

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