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Potassium diformate influences gene expression of GH/IGF-I axis and glucose homeostasis in weaning piglets

文献类型： 外文期刊

作者： Zhou, Yali 1 ; Wei, Xihui 2 ; Zi, Zhenghao 1 ; Zou, Bingjie 1 ; Xia, Shuangshuang 2 ; Lu, Naisheng 1 ; Lei, Hulong 1 ; Lu 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China

2.Nanjing Agr Univ, Coll Anim Sci, Nanjing 210095, Jiangsu, Peoples R China

3.Inst Farm Anim Genet FLI, Dept Funct Genom & Bioregulat, D-31535 Neustadt, Germany

关键词： Potassium diformate;GH/IGF-I axis;Glucose homeostasis;Weaning piglets

期刊名称：LIVESTOCK SCIENCE （ 影响因子：1.943； 五年影响因子：2.252 ）

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收录情况： SCI

摘要： The objective of this study was to determine the effects of potassium diformate (KDF) on growth performance of weaning piglets and genes expression related with growth axis and hepatic gluconeogenesis. A total of 180 piglets weaned at 28 d of age were allocated randomly into two groups, with 6 pens in each group and 15 piglets in each pen. Piglets in the control group were fed basal diet, whereas the KDF-treated group was fed basal diet supplemented with 10 g/kg KDF. After 5 weeks feeding, KDF-treated piglets showed higher average daily feed intake (ADFI) and average daily bodyweight gain (ADG) than those of the control (P < 0.05), whereas the feed conversion ratio (FCR) was lower than that of the control (P=0.02). The apparent digestibility of dry matter and crude protein of the KDF-treated group were higher than those of the control group (P <0.01). KDF treatment did not change the blood indices level of insulin-like growth factor-I (IGF-I), high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG) and blood glucose (BG) in plasma. KDF treatment did not influence the mRNA expression of growth hormone releasing hormone (GHRH) and somatostatin (SS) in hypothalamus, and the levels of growth hormone receptor (GHR) and IGF-I receptor (IGF-IR) mRNA in pituitary. Whereas, it increased the abundance of GH mRNA in pituitary, and the mRNA of GHR, IGF-I, IGF-IR, glucose-6-phosphatase (G6PC), fructose-1,6-bisphosphatase (FBP) and phosphoenolpyruvate carboxykinase (PCK) in liver (P < 0.05). Furthermore, KDF treatment increased the concentration of IGF-I peptide in liver (P=0.000). These results suggest that, the beneficial effect of KDF on the growth performance may relate to the regulation of the GH axis and glucose homeostasis in piglets. (C) 2014 Elsevier B.V. All rights reserved.

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[1]Effects of potassium diformate on the gastric function of weaning piglets. Xia, S.,Zou, B.,Lu, Y.,Lu, N.,Lei, H.,Xia, D.,Xia, S.,Yao, W.,Zou, B..

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