Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of alpha-hemolysin
文献类型： 外文期刊
作者： Wang, J. 1 ; Zhou, X. 1 ; Liu, S. 1 ; Li, G. 1 ; Shi, L. 1 ; Dong, J. 1 ; Li, W. 1 ; Deng, X. 1 ; Niu, X. 2 ;
作者机构： 1.Jilin Univ, Key Lab Zoonosis, Minist Educ, Inst Zoonosis,Coll Vet Med, Changchun 130062, Peoples R China
2.Jilin Univ, Dept Food Qual & Safety, Changchun 130062, Peoples R China
3.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China
关键词： anti-virulence;morin hydrate;Staphylococcus aureus;virulence factor;-hemolysin
期刊名称：JOURNAL OF APPLIED MICROBIOLOGY （ 影响因子：3.772； 五年影响因子：3.963 ）
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收录情况： SCI
摘要： AimsTo investigate the mechanism by which morin hydrate inhibits the haemolytic activity of -hemolysin (Hla), a channel-forming toxin that is important for the pathogenesis of disease in experimental animals, and its therapeutic effect against Staphylococcus aureus pneumonia in a mouse model.
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