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Evaluation of the protective efficacy of four novel identified membrane associated proteins of Streptococcus suis serotype 2

文献类型： 外文期刊

作者： Zhou, Yang 1 ; Wang, Yan 2 ; Deng, Limei 2 ; Zheng, Chengkun 2 ; Yuan, Fangyan 4 ; Chen, Huanchun 2 ; Bei, Weicheng 2 ; L 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

2.Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

3.Huazhong Agr Univ, Coll Food Sci & Technol, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

4.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan 430070, Peoples R China

关键词： Streptococcus suis serotype 2;Membrane associated proteins;Protective antigen

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN：

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收录情况： SCI

摘要： Streptococcus suis serotype 2 (S.suis 2) is an important zoonotic pathogen that can also cause epidemics of life-threatening infections in humans. Surface proteins of pathogens play a critical role in the interaction with host system or environment, as they take part in processes like virulence, cytotoxicity, adhesion, signaling or transport, etc. Thus, surface proteins identified by the screening of immunoproteomic techniques are promising vaccine candidates or diagnostic markers. In this study, four membrane associated proteins (MAP) identified by immunoproteomic method were cloned and expressed as recombinant proteins with his-tag. Screening for vaccine candidates were firstly performed by protection assay in vivo and immunization with Sbp markedly protected mice against systemic S. suis 2 infection. The immune responses and protective of Sbp were further evaluated. The results showed that Sbp could elicit a strong humoral antibody response and protect mice from lethal challenge with S. suis 2. The antiserum against Sbp could efficiently impede survival of bacterial in whole blood killing assay and conferred significant protection against S. suis 2 infection in passive immunization assays. The findings indicate that Sbp may serve as an important factor in the pathogenesis of S. suis 2 and would be a promising subunit vaccine candidate. (C) 2015 Elsevier Ltd. All rights reserved.

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