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Chitosan microparticles ionically cross-linked with poly(gamma-glutamic acid) as antimicrobial peptides and nitric oxide delivery systems

文献类型： 外文期刊

作者： Sun, Yan 1 ; Liu, Yong 2 ; Liu, Wei 2 ; Lu, Chenjie 1 ; Wang, Lei 1 ;

作者机构： 1.Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Polypeptides;Nitric oxide;Control;Antibiotic;Biomedical;Microparticles

期刊名称：BIOCHEMICAL ENGINEERING JOURNAL （ 影响因子：3.978； 五年影响因子：4.084 ）

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收录情况： SCI

摘要： The emergence of antibiotic resistance influences the effective development of therapeutics. In this paper, chitosan (CS) and poly-gamma-glutamic acid (gamma-PGA) composite microparticles were prepared and characterized as carriers for antimicrobial peptides (LL-37) and nitric oxide (NO) delivery systems. Using ionic complexation between the positively charged LL-37 and the negatively charged polyelectrolyte gamma-PGA, gamma-PGA/LL-37 microparticles with negative zeta potentials were produced. Transmission and scanning electron microscopy revealed that complexation of gamma-PGA and LL-37 alone leads to nanostructures with irregular shapes; addition of a third component, CS, is required. gamma-PGA/LL-37 composite microparticles were rewrapped by CS to obtain LL-37 loaded spherical CS/gamma-PGA composite microparticles. NO was further loaded on microparticles by the reaction of NO and LL-37 loaded CS/gamma-PGA composite microparticles under high NO pressure. The results indicated that both LL-37 and NO were co-loaded successfully in microparticles, and the composite particles could sustain LL-37 and NO release at pH 7.4, in vitro. (C) 2014 Published by Elsevier B.V.

  • 相关文献

[1]Synthesis and Characterization of Sugar-Bearing Chitosan Derivatives as a Scaffold for Nitric Oxide Release. Liu, Yong,Sun, Yan. 2011

[2]Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells (Retracted article. See vol 24, pg 281, 2007). Li, Xuebin,Jiang, Yongqing,Wang, Zhengchao,Liu, Gentao,Hutz, Reinhold J.,Liu, Wenbin,Xie, Zhuang,Shi, Fangxiong. 2005

[3]Nitric oxide ameliorates zinc oxide nanoparticles-induced phytotoxicity in rice seedlings. Chen, Juan,Liu, Xiang,Yin, Shan-Shan,Li, Xiu-Ling,Hu, Wen-Jun,Simon, Martin,Shen, Zhi-Jun,Zheng, Hai-Lei,Chen, Juan,Wang, Chao,Hu, Wen-Jun,Xiao, Qiang,Chu, Cheng-Cai,Chu, Cheng-Cai,Peng, Xin-Xiang.

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