文献类型： 外文期刊
作者： Wang, Tuoyi 1 ; Li, Chunyan 2 ; Liu, Yang 2 ; Li, Tiezhu 3 ; Zhang, Jie 3 ; Sun, Yonghai 4 ;
作者机构： 1.Qiqihar Univ, Coll Food & Biol Engn, Qiqihar 161006, Heilongjiang, Peoples R China
2.Qiqihar Med Univ, Clin Pathol Diag Ctr, Qiqihar 161006, Heilongjiang, Peoples R China
3.Jilin Acad Agr Sci, Inst Agrofood Technol, Changchun 130022, Jilin, Peoples R China
4.Jilin Univ, Sch Biol & Agr Engn, Changchun 130022, Jilin, Peoples R China
关键词： Chinese cabbage powder;Vegetable food;Aflatoxin B-1;Antitumor activities;Liver tumor
期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： In this study, 0.25 mu g/ml aflatoxin B-1 was used to establish a liver cancer model for assessing the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 degrees C. We found at least 11 potential anticancer substances in Chinese cabbage powder. A 90-d animal experiment demonstrated that 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, inhibit the formation of aflatoxin B1-DNA adducts in liver cells, and effectively reduce the incidence of liver tumor induced by aflatoxin B-1 from 6.67% to 0%. The dose effect experiment revealed that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors. This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms. (C) 2015 Elsevier Ltd. All rights reserved.
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