文献类型： 外文期刊
作者： Luo, Chuping 1 ; Liu, Xuehui 3 ; Zhou, Xian 4 ; Guo, Junyao 1 ; John Truong 4 ; Wang, Xiaoyu 1 ; Zhou, Huafei 1 ; Li, Xia 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing, Jiangsu, Peoples R China
2.Huaiyin Inst Technol, Sch Life Sci & Chem Engn, Huaian, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China
4.Univ Western Sydney, Natl Inst Complementary Med, Sydney, NSW, Australia
期刊名称：APPLIED AND ENVIRONMENTAL MICROBIOLOGY （ 影响因子：4.792； 五年影响因子：5.26 ）
ISSN：
年卷期：
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收录情况： SCI
摘要： Three families of Bacillus cyclic lipopeptides-surfactins, iturins, and fengycins-have well-recognized potential uses in biotechnology and biopharmaceutical applications. This study outlines the isolation and characterization of locillomycins, a novel family of cyclic lipopeptides produced by Bacillus subtilis 916. Elucidation of the locillomycin structure revealed several molecular features not observed in other Bacillus lipopeptides, including a unique nonapeptide sequence and macrocyclization. Locillomycins are active against bacteria and viruses. Biochemical analysis and gene deletion studies have supported the assignment of a 38-kb gene cluster as the locillomycin biosynthetic gene cluster. Interestingly, this gene cluster encodes 4 proteins (LocA, LocB, LocC, and LocD) that form a hexamodular nonribosomal peptide synthetase to biosynthesize cyclic nonapeptides. Genome analysis and the chemical structures of the end products indicated that the biosynthetic pathway exhibits two distinct features: (i) a nonlinear hexamodular assembly line, with three modules in the middle utilized twice and the first and last two modules used only once and (ii) several domains that are skipped or optionally selected.
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