The HOG-pathway related AaOS1 leads to dicarboximide-resistance in field strains of Alternaria alternata and contributes, together with the Aafhk1, to mycotoxin production and virulence
文献类型： 外文期刊
作者： Wei, Lingling 3 ; Chen, Bin 3 ; Li, Xiujuan 3 ; Shi, Haiping 3 ; Xie, Shuai 3 ; Hu, Hao 3 ; Chen, Wenchan 4 ; Wei, Lihui 4 ; Wang, Xiaoyu 2 ; Chen, Changjun 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Plant Protect, Nanjing 210095, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing 210095, Jiangsu, Peoples R China
3.Nanjing Agr Univ, Coll Plant Protect, Nanjing, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing, Peoples R China
关键词： garlic leaf spot; Alternaria alternata; dicarboximides; mutations; mycotoxin AOH
期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：4.1； 五年影响因子：4.4 ）
ISSN： 1526-498X
年卷期： 2024 年 80 卷 6 期
页码：
收录情况： SCI
摘要： BACKGROUND: Garlic leaf spot (GLS) caused by Alternaria alternata is one of the main diseases in the garlic production areas, and its management heavily relies on dicarboximide fungicides. However, the efficacy of dicarboximides against the GLS disease has decreased year on year. RESULTS: In the present study, 10 of 148 A. alternata strains separated from Jiangsu Province were moderately resistant (MR) to a dicarboximide fungicide procymidone (Pro(MR)). Positive cross-resistance was observed between Pro and iprodione (Ipro) or fludioxonil (Fld), but not between Pro and fluazinam or azoxystrobin. Mutations at AaOS1, but not Aafhk1, were confirmed to confer the Pro resistance by constructing replacement mutants, whereas mutations at both AaOS1 and Aafhk1 decreased the gene expression level of AapksI, as well as the ability to produce mycotoxin AOH (polyketide-derived alternariol) and virulence. Additionally, more genes (AaOS1 and Aafhk1) harboring the mutations experienced a larger biological fitness penalty. CONCLUSION: To our knowledge, this is the first report on Pro resistance selected in garlic fields, and mutations at AaOS1 of A. alternata causing a decreased ability to produce the mycotoxin AOH. (c) 2024 Society of Chemical Industry.
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