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Nanoparticles in the fight against mosquito-borne diseases: bioactivity of Bruguiera cylindrica-synthesized nanoparticles against dengue virus DEN-2 (in vitro) and its mosquito vector Aedes aegypti (Diptera: Culicidae)

文献类型： 外文期刊

作者： Murugan, Kadarkarai 1 ; Dinesh, Devakumar 1 ; Paulpandi, Manickam 1 ; Althbyani, Abdulaziz Dakhellah Meqbel 2 ;

作者机构： 1.Bharathiar Univ, Dept Zool, Sch Life Sci, Coimbatore 641046, Tamil Nadu, India

2.Univ Tabuk, Dept Biol, Fac Sci, Tabuk 71491, Saudi Arabia

3.Shanxi Univ, Sch Life Sci & Technol, Taiyuan 030006, Peoples R China

4.Fujian Acad Agr Sci, Inst Plant Protect, Fuzhou 350013, Fujian, Peoples R China

5.Natl Taiwan Ocean Univ, Inst Marine Biol, Keelung 20224, Taiwan

6.Texas A&M Univ Syst, Agri Lif

关键词： Antiviral activity;Biotoxicity;Nanobiotechnology;Nontarget effect;severe dengue;EDX;FTIR;SEM;XRD

期刊名称：PARASITOLOGY RESEARCH （ 影响因子：2.289； 五年影响因子：2.403 ）

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收录情况： SCI

摘要： Mosquitoes are blood-feeding insects serving as the most important vectors for spreading human pathogens and parasites. Dengue is a viral disease mainly vectored through the bite of Aedes mosquitoes. Its transmission has recently increased in urban and semi-urban areas of tropical and subtropical regions worldwide, becoming a major international public health concern. There is no specific treatment for dengue. Its prevention and control solely depend on effective vector control measures. Mangrove plants have been used in Indian traditional medicine for a wide array of purposes. In this research, we proposed a method for biosynthesis of antiviral and mosquitocidal silver nanoparticles (AgNP) using the aqueous extract of Bruguiera cylindrica leaves. AgNP were characterized using a variety of biophysical analyses, including UV-visible spectrophotometry, Fourier-transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Bruguiera cilyndrica aqueous extract and green-synthesized AgNP were tested against the primary dengue vector Aedes aegypti. AgNP were the most effective. LC50 values ranged from 8.93 ppm (larva I) to 30.69 ppm (pupa). In vitro experiments showed that 30 mu g/ml of AgNP significantly inhibited the production of dengue viral envelope (E) protein in vero cells and downregulated the expression of dengue viral E gene. Concerning nontarget effects, we observed that the predation efficiency of Carassius auratus against A. aegypti was not affected by exposure at sublethal doses of AgNP. Predation in the control was 71.81 % (larva II) and 50.43 % (larva III), while in an AgNP-treated environment, predation was boosted to 90.25 and 76.81 %, respectively. Overall, this study highlights the concrete potential of green-synthesized AgNP in the fight against dengue virus. Furthermore, B. cylindrica-synthesized AgNP can be employed at low doses to reduce larval and pupal population of A. aegypti, without detrimental effects of predation rates of mosquito predators, such as C. auratus.

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[2]Characterization and biotoxicity of Hypnea musciformis-synthesized silver nanoparticles as potential eco-friendly control tool against Aedes aegypti and Plutella xylostella. Roni, Mathath,Murugan, Kadarkarai,Panneerselvam, Chellasamy,Subramaniam, Jayapal,Madhiyazhagan, Pani,Dinesh, Devakumar,Suresh, Udaiyan,Nicoletti, Marcello,Khater, Hanem F.,Wei, Hui,Canale, Angelo,Benelli, Giovanni,Alarfaj, Abdullah A.,Munusamy, Murugan A.,Higuchi, Akon.

[3]Characterization and mosquitocidal potential of neem cake-synthesized silver nanoparticles: genotoxicity and impact on predation efficiency of mosquito natural enemies. Chandramohan, Balamurugan,Murugan, Kadarkarai,Panneerselvam, Chellasamy,Madhiyazhagan, Pari,Chandirasekar, Ramachandran,Dinesh, Devakumar,Kumar, Palanisamy Mahesh,Kovendan, Kalimuthu,Suresh, Udaiyan,Subramaniam, Jayapal,Rajaganesh, Rajapandian,Aziz, Al Thabiani,Syuhei, Ban,Alsalhi, Mohamad Saleh,Devanesan, Sandhanasamy,Nicoletti, Marcello,Wei, Hui,Benelli, Giovanni.

[4]Do Chenopodium ambrosioides-Synthesized Silver Nanoparticles Impact Oryzias melastigma Predation Against Aedes albopictus Larvae?. Subramaniam, Jayapal,Jebanesan, Arulsamy,Subramaniam, Jayapal,Murugan, Kadarkarai,Pontheckan, Philips,Dinesh, Devakumar,Murugan, Kadarkarai,Nicoletti, Marcello,Wei, Hui,Higuchi, Akon,Kumar, Suresh,Canale, Angelo,Benelli, Giovanni.

[5]Mosquitocidal, Antimalarial and Antidiabetic Potential of Musa paradisiaca-Synthesized Silver Nanoparticles: In Vivo and In Vitro Approaches. Anbazhagan, Priya,Murugan, Kadarkarai,Jaganathan, Anitha,Sujitha, Vasu,Samidoss, Christina Mary,Jayashanthani, Sudalaimani,Amuthavalli, Pandian,Murugan, Kadarkarai,Higuchi, Akon,Kumar, Suresh,Wei, Hui,Nicoletti, Marcello,Canale, Angelo,Benelli, Giovanni,Benelli, Giovanni.

[6]In vivo and in vitro effectiveness of Azadirachta indica-synthesized silver nanocrystals against Plasmodium berghei and Plasmodium falciparum, and their potential against malaria mosquitoes. Murugan, Kadarkarai,Samidoss, Christina Mary,Madhiyazhagan, Pari,Suresh, Udaiyan,Roni, Mathath,Chandramohan, Balamurugan,Subramaniam, Jayapal,Dinesh, Devakumar,Rajaganesh, Rajapandian,Paulpandi, Manickam,Panneerselvam, Chellasamy,Aziz, Thabiani,Wei, Hui,Alsalhi, Mohamad Saleh,Devanesan, Sandhanasamy,Nicoletti, Marcello,Pavela, Roman,Canale, Angelo,Benelli, Giovanni.

[7]Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors. Murugan, Kadarkarai,Paulpandi, Manickam,Samidoss, Christina Mary,Dinesh, Devakumar,Chandramohan, Balamurugan,Subramaniam, Jayapal,Vadivalagan, Chithravel,Amuthavalli, Pandiyan,Jaganathan, Anitha,Wei, Jiang,Alsalhi, Mohamad Saleh,Devanesan, Sandhanasamy,Nicoletti, Marcello,Paneerselvam, Chellasamy,Aziz, Al Thabiani,Wei, Hui,Higuchi, Akon,Kumar, Suresh,Nataraj, Devaraj,Vaseeharan, Baskaralingam,Canale, Angelo,Benelli, Giovanni.

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