Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions
文献类型： 外文期刊
作者： Dong, Gang 1 ; Chen, Hong 2 ; Qi, Meiyu 3 ; Dou, Ye 2 ; Wang, Qinglu 2 ;
作者机构： 1.Shandong Wanjie Med Coll, Dept Oral Med, Zibo 255213, Shandong, Peoples R China
2.Shandong Wanjie Med Coll, Key Lab Biomed Engn & Technol Shandong High Sch, Zibo 255213, Shandong, Peoples R China
3.Heilongjiang Acad Agr Sci, Cattle Res Dept, Anim Husb Inst, Harbin 150086, Heilongjiang, Peoples R China
关键词： metallothionein;metal response element-binding transcription factor-1;Zn2+;metal ion metabolism
期刊名称：MOLECULAR MEDICINE REPORTS （ 影响因子：2.952； 五年影响因子：2.754 ）
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收录情况： SCI
摘要： Metal ion homeostasis and heavy metal detoxification systems are regulated by certain genes associated with metal ion transport. Metallothionein (MT) and metal response element binding transcription factor 1 (MTF-1) are important regulatory proteins involved in the mediation of intracellular metal ion balance. Differences in the zinc-binding affinities of the zinc fingers of MTF-1 and the alpha- and beta-domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intracellular concentration of Zn2+ influence the MTF-1 zinc finger number, and MTF-1 containing certain zinc finger numbers regulates the expression of corresponding target genes. The present review evaluates the association between zinc finger number in MTF-1 protein, MTF-1 target genes and the mechanism underlying. MT regulation of the zinc finger number in MTF-1.
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