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Effect of retS gene on antibiotics production in Pseudomonas fluorescens FD6

文献类型： 外文期刊

作者： Zhang, Qingxia 1 ; Xiao, Qi 1 ; Xu, Jingyou 1 ; Tong, Yunhui 1 ; Wen, Jia 2 ; Chen, Xijun 1 ; Wei, Lihui 3 ;

作者机构： 1.Yangzhou Univ, Coll Plant Protect & Hort, Yangzhou 225009, Jiangsu, Peoples R China

2.Hunan Univ, Coll Environm Sci & Engn, Changsha 410082, Hunan, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing 210014, Peoples R China

关键词： Pseudomonas;Antibiotics;RetS;Gac/Rsm

期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：5.415； 五年影响因子：6.038 ）

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收录情况： SCI

摘要： A hybrid sensor kinase termed RetS (regulator of exopolysaccharide and Type III secretion) controls expression of numerous genes in Pseudomonas aeruginosa. To investigate the function of RetS in P. fluorescens FD6, the retS gene was disrupted. Genetic inactivation of retS resulted in enhanced production of 2, 4-diacetylphloroglucinol, pyrrolnitrin, and pyoluteorin. The retS mutant also exhibited significant increase in ph1A-lacZ, prnA-lacZ, and pltA-lacZ transcription levels, influencing expression levels of the small regulatory RNAs RsmX and RsmZ. In the gacSretS double mutant, all the phenotypic changes caused by the retS deletion were reversed to the level of gacS single mutant. Furthermore, the retS mutation drastically elevated biofilm formation and improved the colonization ability of strain FD6 on wheat rhizospheres. Based on these results, we proposed that RetS negatively controlled the production of antibiotics through the Gac/Rsm pathway in P. fluorescens FD6. (C) 2015 Elsevier GmbH. All rights reserved.

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[1]Role of Vfr in the regulation of antifungal compound production by Pseudomonas fluorescens FD6. Zhang, Qingxia,Ji, Yanyan,Xiao, Qi,Tong, Yunhui,Chen, Xijun,Chng, Soonie,Liu, Fengquan.

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