您好,欢迎访问中国水产科学研究院 机构知识库!

Pharmacokinetics of cefquinome in tilapia (Oreochromis niloticus) after a single intramuscular or intraperitonealadministration

文献类型: 外文期刊

作者: Shan, Q. 1 ; Zhu, X. 1 ; Liu, S. 1 ; Bai, Y. 1 ; Ma, L. 1 ; Yin, Y. 1 ; Zheng, G. 1 ;

作者机构: 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Key Lab Trop & Subtrop Fishery Resource Applicat, Guangzhou 510380, Guangdong, Peoples R China

2.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Lab Qual & Safety Risk Assessment Aquat Prod, Guangzhou 510380, Guangdong, Peoples R China

期刊名称:JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS ( 2020影响因子:1.786; 五年影响因子:1.7 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The pharmacokinetics of cefquinome was studied in plasma after a single dose (10mg/kg) of intramuscular (i.m.) or intraperitoneal (i.p.) administration to tilapia (Oreochromis niloticus) in freshwater at 30 degrees C. Ten fish per sampling point were examined after treatment. The data were fitted to two-compartment open models following both routes of administration. The estimates of total body clearance (CL/F), volume of distribution (Vd/F), and absorption half-life (T-1/2ka) were 0.049 and 0.037L/h/kg, 0.41 and 0.33L/kg, and 0.028 and 0.035h following i.m. and i.p. administration, respectively. After i.m. injection, the elimination half-life (T-1/2) was calculated to be 5.81h, the maximum plasma concentration (C-max) to be 49.40g/mL, the time to peak plasma cefquinome concentration (T-max) to be 0.14h, and the area under the plasma concentration-time curve (AUC) to be 204.6gh/mL. Following i.p. administration, the corresponding estimates were 6.05h, 44.39g/mL, 0.17h and 267.8gh/mL. The minimum inhibitory concentrations of cefquinome, determined for 30 strains of Streptococcus agalactiae isolated from diseased tilapia, ranged from 0.015 to 0.12g/mL. Results from these studies support that 10mg cefquinome/kg body weight daily could be expected to control tilapia bacterial pathogens inhibited invitro by a minimal inhibitory concentration value of 2g/mL.

  • 相关文献
作者其他论文 更多>>