文献类型： 外文期刊
作者： Cheng, Zhong-Quan 2 ; Yang, Dan 3 ; Ma, Qing-Yun 1 ; Dai, Hao-Fu 1 ; Huang, Sheng-Zhuo 1 ; Yi, Xiang-Hui 3 ; Zhou, Jun 2 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Guilin Normal Coll, Dept Chem & Engn, Guilin, Peoples R China
关键词： Dobinea delavayi;Podoaceae;sesquiterpenes;anti-cancer activity
期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）
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年卷期：
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收录情况： SCI
摘要： Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 x 10(-5), 4.7 x 10(-5), and 5.1 x 10(-5) M, respectively.
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