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Three New Sesquiterpenes with Cytotoxic Activity from Dobinea delavayi

文献类型: 外文期刊

作者: Cheng, Zhong-Quan 2 ; Yang, Dan 3 ; Ma, Qing-Yun 1 ; Dai, Hao-Fu 1 ; Huang, Sheng-Zhuo 1 ; Yi, Xiang-Hui 3 ; Zhou, Jun 2 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

3.Guilin Normal Coll, Dept Chem & Engn, Guilin, Peoples R China

关键词: Dobinea delavayi;Podoaceae;sesquiterpenes;anti-cancer activity

期刊名称:PLANTA MEDICA ( 影响因子:3.352; 五年影响因子:3.4 )

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收录情况: SCI

摘要: Three new sesquiterpenes dobinins A-C (1-3), together with five known compounds, were isolated from the root of Dobinea delavayi. The structures of the three new compounds were determined on the basis of spectroscopic analysis including 1D-, 2D-NMR and MS techniques as well as by comparison of the spectral data with those of analogous compounds reported in the literatures. Compounds 1-3 were screened for antitumor activity in vitro and exhibited definite cytotoxic activity against the human tumor cell line HL-60 with IC50 levels of 8.0 x 10(-5), 4.7 x 10(-5), and 5.1 x 10(-5) M, respectively.

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