文献类型： 外文期刊

作者： Jia, Z. -Y. ¹ ; Ge, H. -Z. ¹ ; Bai, Y. -Y. ¹ ; Li, C. -T. ¹ ; Shi, L. -Y. ¹ ;

作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Harbin 150070, Peoples R China

2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China

期刊名称：JOURNAL OF APPLIED ICHTHYOLOGY （ 影响因子：0.892； 五年影响因子：0.956 ）

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收录情况： SCI

摘要： Single nucleotide polymorphisms of Interleukin-1 beta (IL-1 beta) have been reported as markers for susceptibility to infectious diseases in humans and livestock. The present study was to determine the genetic variation of this cytokine in six carp strains. Among the sampled individuals, a total of 13 SNPs, including eight in introns and five in coding regions, were identified at intron 5, exon 6, intron 6 and exon 7. Three positions of 1700, 1733 and 1934 resulted in variable amino acid changes with Phe to Tyr, Pro to Leu and Lys to Asn, respectively. Five positions with minor allele frequency (MAF) were larger than 0.05. Among 13 SNPs, eight positions of allele frequency and ten positions of genotypic frequency showed significant differences between some populations. The genotype distributions of the 13 SNPs were consistent with the assumption of the Hardy-Weinberg equilibrium, with the exception of two positions in the Yibu and bighead carp (P < 0.05), so as to supply the genetic information for research on infectious diseases.