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Anti-HIV terpenoids from Daphne aurantiaca Diels. stems

文献类型: 外文期刊

作者: Huang, Sheng-Zhuo 1 ; Zhang, Xuan 2 ; Ma, Qing-Yun 1 ; Zheng, Yong-Tang 3 ; Dai, Hao-Fu 1 ; Wang, Qi 1 ; Zhou, Jun; Zh 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Peoples R China

2.Chinese Acad Sci, Kunming Inst Zool, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming 650204, Peoples R China

3.Chinese Acad Sci, Kunming Inst Zool, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Key Lab Anim Models & Human Dis Mech Chin

期刊名称:RSC ADVANCES ( 影响因子:3.361; 五年影响因子:3.39 )

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收录情况: SCI

摘要: Thirteen new sesquiterpenoids, including six guaiane type auranticanols A-F (1, 2, and 4-7) and seven carotene type auranticanols G-M (18-24) were isolated from the stems of Daphne aurantiaca Diels., along with fourteen known sesquiterpenoids (3, 8-17, 25-27) and two known tigliane diterpenoids (28, 29), and their structures were elucidated by extensively analyzing their MS and NMR spectroscopic data. A bioassay of anti-HIV activity indicated that compounds 11, 14, 19, and 28 showed definite activities with EC50 values of 2.138, 0.286, 1.773 and 0.000282 mu g mL(-1) and SI > 93.545, 93.787, 10.243, and 65 177.305, respectively.

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