文献类型： 外文期刊
作者： Yi, Yang 1 ; Wang, Hongxun 1 ; Zhang, Ruifen 3 ; Min, Ting 1 ; Huang, Fei 3 ; Liu, Lei 3 ; Zhang, Mingwei 3 ;
作者机构： 1.Wuhan Polytech Univ, Coll Food Sci Engn, Wuhan 430023, Peoples R China
2.Hubei Collaborat Innovat Ctr Proc Agr Prod, Wuhan 430023, Peoples R China
3.Guangdong Acad Agr Sci, Minist Agr, Sericultural & Agri Food Res Inst, Key Lab Funct Food, Guangzhou 510610, Guangdong, Peoples R China
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Longan is one of the most popular subtropical fruits in Southeast Asia, because of its flavor and benefits to health. As one of the important active ingredients of longan pulp, polysaccharide LPIIa was obtained by hot water extraction, ion-exchange chromatography and gel filtration chromatography. Its physicochemical characterization and immunostimulatory effects on macrophages were then investigated. Structural analyses indicated that LPIIa was a 44.7 kDa heteropolysaccharide mainly composed of -> 6)-Glc-(1 ->, -> 5)-Ara-(1 ->, -> 4)-Man-(1 -> and -> 6)-Gal-(1 ->. It enhanced macrophage phagocytosis and nitric oxide production in the dose range of 100-400 mu g mL(-1). Moreover, it significantly increased the inducible nitric oxide synthase activity, tumor necrosis factor-alpha and interleukin-6 secretion of macrophages at 200 mu g mL(-1). However, these effects were obviously weakened after toll-like receptor 4 (TLR4) or TLR2 was blocked. Likewise, the specific inhibitors of p38 mitogen-activated protein kinase (MAPK), protein kinase C, phosphatidylinositol 3-kinase, protein tyrosine kinase and nuclear factor kappa B (NF-kappa B) selectively depressed the immunostimulatory activities of LPIIa on macrophages. LPIIa stimulated macrophage activation partly via TLR4 and TLR2, followed by p38 MAPK- and NF-kappa B-dependent signaling pathways. The results suggested that LPIIa possessed potent immunomodulatory activity by stimulating macrophages and could be used as an immunotherapeutic adjuvant.
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