文献类型： 外文期刊
作者： Dong, Jing 1 ; Zhang, Yong 1 ; Chen, Yutao 3 ; Niu, Xiaodi 4 ; Zhang, Yu 1 ; Yang, Cheng 5 ; Wang, Quan 3 ; Li, Xuemei 3 ; D 1 ;
作者机构： 1.Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 130023, Peoples R China
2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100080, Peoples R China
4.Jilin Univ, Dept Food Qual & Safety, Changchun 130023, Peoples R China
5.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China
期刊名称：ANTIMICROBIAL AGENTS AND CHEMOTHERAPY （ 影响因子：5.191； 五年影响因子：5.346 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Shiga-like toxins (Stxs), produced by pathogenic Escherichia coli, are a major virulence factor involved in severe diseases in human and animals. These toxins are ribosome-inactivating proteins, and treatment for diseases caused by them is not available. Therefore, there is an urgent need for agents capable of effectively targeting this lethal toxin. In this study, we identified baicalin, a flavonoid compound used in Chinese traditional medicine, as a compound against Shiga-like toxin 2 (Stx2). We found that baicalin significantly improves renal function and reduces Stx2-induced lethality in mice. Further experiments revealed that baicalin induces the formation of oligomers by the toxin by direct binding. We also identified the residues important for such interactions and analyzed their roles in binding baicalin by biophysical and biochemical analyses. Our results establish baicalin as a candidate compound for the development of therapeutics against diseases caused by Stxs.
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