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The Selenylation Modification of Epimedium Polysaccharide and Isatis Root Polysaccharide and the Immune-enhancing Activity Comparison of Their Modifiers

文献类型： 外文期刊

作者： Li, Xiuping 1 ; Hou, Ranran 1 ; Yue, Chanjuan 1 ; Liu, Jie 1 ; Gao, Zhenzhen 1 ; Chen, Jin 3 ; Lu, Yu 4 ; Wang, Deyun 1 ; Li 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China

2.Dezhou Univ, Dept Agr, Dezhou 253023, Peoples R China

3.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Jiangsu, Peoples R China

4.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol

关键词： Epimedium polysaccharide;Isatis root polysaccharide;Selenylation modification;Lymphocyte proliferation;Antibody titer

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.738； 五年影响因子：3.44 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Epimedium polysaccharide (EPS) and isatis root polysaccharide (IRPS) were extracted, purified, and selenizingly modified by nitric acid-sodium selenite method to obtain nine selenizing EPSs (sEPSs), sEPS(1)-sEPS(9) and nine selenizing IRPSs (sIRPSs), sIRPS(1)-sIRPS(9), respectively. Their effects on chicken peripheral lymphocyte proliferation in vitro were compared by MTT assay. The results showed that selenium polysaccharides at appropriate concentration could promote lymphocyte proliferation more significantly than unmodified polysaccharides, sEPS(5) and sIRPS(5) with stronger actions were picked out and injected into the chickens vaccinated with Newcastle disease vaccine in vivo tests. The peripheral lymphocyte proliferation and serum antibody titer were determined. The results showed that sEPS(5) and sIRPS(5) could elevate serum antibody titer and promote lymphocyte proliferation more significantly than unmodified polysaccharides, sEPS(5) possessed the strongest efficacy. These results indicate that selenylation modification can significantly enhance the immune-enhancing activity of EPS and IRPS, and sEPS(5) can be as a new-type immunopotentiator of chickens.

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