New Phragmalin-Type Limonoids from Chukrasia tabularis and Their alpha-Glucosidase Inhibitory Activity
文献类型： 外文期刊
作者： Peng, Jun-Lin 1 ; Wang, Jun 1 ; Kong, Fan-Dong 1 ; Liu, Zi-Qi; Wang, Pei 1 ; Gai, Cui-Juan 1 ; Jiang, Bei; Mei, Wen 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China
2.Dali Univ
关键词： Chukrasia tabularis;Meliaceae;limonoid;-Glucosidase inhibition activity
期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）
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年卷期：
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收录情况： SCI
摘要： Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro -glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against -glucosidase with IC50 values of 0.06 +/- 0.008, 0.04 +/- 0.002, 0.52 +/- 0.039, 1.09 +/- 0.040, and 0.20 +/- 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 +/- 0.092 mM).
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