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New Phragmalin-Type Limonoids from Chukrasia tabularis and Their alpha-Glucosidase Inhibitory Activity

文献类型： 外文期刊

作者： Peng, Jun-Lin 1 ; Wang, Jun 1 ; Kong, Fan-Dong 1 ; Liu, Zi-Qi; Wang, Pei 1 ; Gai, Cui-Juan 1 ; Jiang, Bei; Mei, Wen 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

2.Dali Univ

关键词： Chukrasia tabularis;Meliaceae;limonoid;-Glucosidase inhibition activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro -glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against -glucosidase with IC50 values of 0.06 +/- 0.008, 0.04 +/- 0.002, 0.52 +/- 0.039, 1.09 +/- 0.040, and 0.20 +/- 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 +/- 0.092 mM).

  • 相关文献

[1]Two new phragmalin-type limonoids from Chukrasia tabularis and their alpha-glucosidase inhibitory activity. Peng, Jun-Lin,Wang, Jun,Mei, Wen-Li,Kong, Fan-Dong,Wang, Pei,Gai, Cui-Juan,Dai, Hao-Fu,Peng, Jun-Lin,Liu, Zi-Qi,Jiang, Bei.

[2]Two new phragmalin-type limonoids from stems of Chukrasia tabularis. Peng, Jun-Lin,Jun-Wang,Kong, Fan-Dong,Wang, Pei,Gai, Cui-Juan,Mei, Wen-li,Dai, Hao-fu,Peng, Jun-Lin,Liu, Zi-Qi,Jiang, Bei.

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[5]Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis. Liu, Shou-Bai,Wang, Zhu-Nian,Liu, Shou-Bai,Mei, Wen-Li,Chen, Hui-Qin,Guo, Zhi-Kai,Dai, Hao-Fu.

[6]Terpenoids and their anti-feedant activity from Cipadessa cinerascens. Fu, Lin-Ran,Yu, Zhi-Fang,Ma, Qing-Yun,Huang, Sheng-Zhuo,Dai, Hao-Fu,Guo, Zhi-Kai,Zhao, You-Xing.

[7]Vegetative Storage Proteins in Meliaceae. Tian, WM,Wu, JL,Hao, BZ,Hu, ZH.

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