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New Phragmalin-Type Limonoids from Chukrasia tabularis and Their alpha-Glucosidase Inhibitory Activity

文献类型: 外文期刊

作者: Peng, Jun-Lin 1 ; Wang, Jun 1 ; Kong, Fan-Dong 1 ; Liu, Zi-Qi; Wang, Pei 1 ; Gai, Cui-Juan 1 ; Jiang, Bei; Mei, Wen 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

2.Dali Univ

关键词: Chukrasia tabularis;Meliaceae;limonoid;-Glucosidase inhibition activity

期刊名称:MOLECULES ( 影响因子:4.411; 五年影响因子:4.587 )

ISSN:

年卷期:

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收录情况: SCI

摘要: Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro -glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against -glucosidase with IC50 values of 0.06 +/- 0.008, 0.04 +/- 0.002, 0.52 +/- 0.039, 1.09 +/- 0.040, and 0.20 +/- 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 +/- 0.092 mM).

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