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In vivo and in vitro effectiveness of Azadirachta indica-synthesized silver nanocrystals against Plasmodium berghei and Plasmodium falciparum, and their potential against malaria mosquitoes

文献类型： 外文期刊

作者： Murugan, Kadarkarai 1 ; Panneerselvam, Chellasamy 2 ; Samidoss, Christina Mary 1 ; Madhiyazhagan, Pari 1 ; Sures 1 ;

作者机构： 1.Bharathiar Univ, Sch Life Sci, Div Entomol, Dept Zool, Coimbatore 641046, Tamil Nadu, India

2.Univ Tabuk, Dept Biol, Fac Sci, Tabuk 71491, Saudi Arabia

3.Univ Tabuk, Dept Biol, Fac Sci, Tab

关键词： Arbovirus;Anopheles stephensi;Botanical byproducts;Culicidae;Filariasis;Nanobiotechnology

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

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收录情况： SCI

摘要： Malaria transmission is a serious emergence in urban and semiurban areas worldwide, becoming a major international public health concern. Malaria is transmitted through the bites of Anopheles mosquitoes. The extensive employ of synthetic pesticides leads to negative effects on human health and the environment. Recently, plant synthesized nanoparticles have been proposed as highly effective mosquitocides. In this research, we synthesized silver nanoparticles (AgNP) using the Azadirachta indica seed kernel extract as reducing and stabilizing agent. AgNP were characterized by UV-vis spectrophotometry, SEM, EDX, XRD and FTIR spectroscopy. The A. indica seed kernel extract was toxic against Anopheles stephensi larvae and pupae, LC50 were 232.8 ppm (larva I), 260.6 ppm (II), 290.3 ppm (III), 323.4 ppm (IV), and 348.4 ppm (pupa). AgNP LC50 were 3.9 ppm (I), 4.9 ppm (II), 5.6 ppm (III), 6.5 ppm (IV), and 8.2 ppm (pupa). The antiplasmodial activity of A. indica seed kernel extract and AgNP was evaluated against CQ-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. IC50 of A. indica seed kernel extract were 63.18 mu g/ml (CQ-s) and 69.24 mu g/ml (CQ-r). A. indica seed kernel synthesized AgNP achieved IC50, of 82.41 mu g/ml (CQ-s) and 86.12 mu g/ml (CQ-r). However, in vivo anti plasmodia] experiments conducted on Plasmodium berghei infecting albino mice showed moderate activity of the A. indica extract and AgNP. Overall, this study showed that the A. indica-mediated fabrication of AgNP is of interest for a wide array of purposes, ranging from IPM of mosquito vectors to the development of novel and cheap antimalarial drugs. (C) 2016 Elsevier Ltd. All rights reserved.

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[1]Fabrication of nano-mosquitocides using chitosan from crab shells: Impact on non-target organisms in the aquatic environment. Murugan, Kadarkarai,Anitha, Jaganathan,Dinesh, Devakumar,Suresh, Udaiyan,Rajaganesh, Rajapandian,Chandramohan, Balamurugan,Subramaniam, Jayapal,Paulpandi, Manickam,Vadivalagan, Chitravel,Amuthavalli, Pandiyan,Murugan, Kadarkarai,Wang, Lan,Hwang, Jiang-Shiou,Wei, Hui,Alsalhi, Mohamad Saleh,Devanesan, Sandhanasamy,Kumar, Suresh,Pugazhendy, Kannaiyan,Higuchi, Akon,Nicoletti, Marcello,Benelli, Giovanni,Benelli, Giovanni.

[2]Biosynthesis, characterization, and acute toxicity of Berberis tinctoria-fabricated silver nanoparticles against the Asian tiger mosquito, Aedes albopictus, and the mosquito predators Toxorhynchites splendens and Mesocyclops thermocyclopoides. Kumar, Palanisamy Mahesh,Murugan, Kadarkarai,Madhiyazhagan, Pari,Kovendan, Kalimuthu,Amerasan, Duraisamy,Chandramohan, Balamurugan,Dinesh, Devakumar,Suresh, Udaiyan,Nicoletti, Marcello,Alsalhi, Mohamad Saleh,Devanesan, Sandhanasamy,Wei, Hui,Kalimuthu, Kandasamy,Hwang, Jiang-Shiou,Lo Iacono, Annalisa,Benelli, Giovanni.

[3]Mosquitocidal, Antimalarial and Antidiabetic Potential of Musa paradisiaca-Synthesized Silver Nanoparticles: In Vivo and In Vitro Approaches. Anbazhagan, Priya,Murugan, Kadarkarai,Jaganathan, Anitha,Sujitha, Vasu,Samidoss, Christina Mary,Jayashanthani, Sudalaimani,Amuthavalli, Pandian,Murugan, Kadarkarai,Higuchi, Akon,Kumar, Suresh,Wei, Hui,Nicoletti, Marcello,Canale, Angelo,Benelli, Giovanni,Benelli, Giovanni.

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[5]Seaweed-synthesized silver nanoparticles: an eco-friendly tool in the fight against Plasmodium falciparum and its vector Anopheles stephensi?. Murugan, Kadarkarai,Samidoss, Christina Mary,Panneerselvam, Chellasamy,Roni, Mathath,Suresh, Udaiyan,Chandramohan, Balamurugan,Subramaniam, Jayapal,Madhiyazhagan, Pari,Dinesh, Devakumar,Rajaganesh, Rajapandian,Higuchi, Akon,Alarfaj, Abdullah A.,Nicoletti, Marcello,Kumar, Suresh,Wei, Hui,Canale, Angelo,Benelli, Giovanni,Mehlhorn, Heinz.

[6]Genetic deviation in geographically close populations of the dengue vector Aedes aegypti (Diptera: Culicidae): influence of environmental barriers in South India. Vadivalagan, Chithravel,Murugan, Kadarkarai,Panneerselvam, Chellasamy,Paulpandi, Manickam,Madhiyazhagan, Pari,Dinesh, Devakumar,Karthika, Pushparaj,Wei, Hui,Aziz, Al Thabiani,Alsalhi, Mohamad Saleh,Devanesan, Sandhanasamy,Nicoletti, Marcello,Paramasivan, Rajaiah,Benelli, Giovanni.

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