Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus
文献类型： 外文期刊
作者： Zhao, Yangyang 1 ; Qian, Guoliang 1 ; Ye, Yonghao 1 ; Wright, Stephen 2 ; Chen, Haotong 2 ; Shen, Yuemao 3 ; Liu, Feng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Plant Protect, Nanjing 210095, Jiangsu, Peoples R China
2.Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
3.Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Jinan 250100, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing 210014, Jiangsu, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Heterocyclic aromatic N-oxides often have potent biological activities, but the mechanism for aromatic N-oxidation is unclear. Six phenazine antibiotics were isolated from Lysobacter antibioticus OH13. A 10 gene cluster was identified for phenazine biosynthesis. Mutation of LaPhzNO1 abolished all N-oxides, while non-oxides markedly increased. LaPhzNO1 is homologous to Baeyer-Villiger flavoproteins but was shown to catazlye phenazine N-oxidation. LaPhzNO1 and LaPhzS together converted phenazine 1,6-dicarboxylic acid to 1,6-dihydroxyphenazine N5,N10-dioxide. LaPhzNO1 also catalyzed N-oxidation of 8-hydroxyquinoline.
- 相关文献
作者其他论文 更多>>
-
The natural polycyclic tetramate macrolactam HSAF inhibit Fusarium graminearum through altering cell membrane integrity by targeting FgORP1
作者：Chen, Wenchan;Tang, Bao;Hou, Rongxian;Sun, Weibo;Guo, Baodian;Zhao, Yangyang;Li, Chaohui;Sheng, Cong;Zhao, Yancun;Liu, Fengquan;Liu, Fengquan;Han, Chenyang
关键词：F. graminearum; HSAF; FgORP1; Ergosterol; Cell membrane
-
Join the green team: Inducers of plant immunity in the plant disease sustainable control toolbox
作者：Zhu, Feng;Cao, Meng-Yao;Zhang, Qi-Ping;Mohan, Rajinikanth;Mitchell, Michaela;Schar, Jacob;Chen, Huan;Fu, Zheng Qing;Chen, Huan;Liu, Fengquan;Wang, Daowen;Wang, Daowen
关键词：Disease sustainable control; Food security; Inducers of plant immunity; Plant immunity; Plant diseases; Green technologies
-
Old role with new feature: T2SS ATPase as a cyclic-di-GMP receptor to regulate antibiotic production
作者：Liu, Haofei;Liu, Fengquan;Xu, Gaoge;Guo, Baodian;Liu, Fengquan;Xu, Gaoge;Liu, Fengquan
关键词：c-di-GMP; receptor proteins; T2SS GspE; antifungal antibiotic
-
First Report of Bacterial Fruit Blotch Caused by Kosakonia cowanii on Trichosanthis fructus in Jiangsu Province, China
作者：Chen, Xian;Tang, Bao;Zhao, Yancun;Liu, Fengquan;Chen, Xian;Tang, Bao;Laborda, Pedro
关键词：bacterial fruit blotch; Kosakonia cowanii; Trichosanthis fructus
-
Unveiling the Role of Diffusible Signal Factor-Family Quorum Sensing Signals in Regulating Behavior of Xanthomonas and Lysobacter
作者：Li, Kaihuai;Ma, Chaoyun;Xiong, Chunlan;Zhou, Xue;Wang, Yong;Liu, Fengquan;Li, Kaihuai;Ma, Chaoyun;Xiong, Chunlan;Zhou, Xue;Wang, Yong;Liu, Fengquan;Li, Kaihuai;Wang, Yong;Mao, Yahui;Liu, Fengquan
关键词：diffusible signal factor; Lysobacter enzymogenes; quorum sensing; Xanthomonas campestris
-
Molecular Mechanism of Fusarium Fungus Inhibition by Phenazine-1-carboxamide
作者：Li, Lei;Yin, Mengyu;Yu, Wei;Zou, Jingpei;Ye, Yonghao;Zhang, Feng;Ran, Tingting;Wang, Weiwu;Zhu, Hong;Li, Linwei;Sun, Hao;Guo, Jingjing
关键词：phenazine-1-carboxamide; histone acetyltransferase Gcn5; inhibition; development; pathogenicity; DON production; Fusarium graminearum
-
S-nitrosylation of a receptor-like cytoplasmic kinase regulates plant immunity
作者：Cui, Beimi;Liu, Fengquan;Cui, Beimi;Liu, Fengquan;Cui, Beimi;Pan, Qiaona;Loake, Gary J.;Cui, Wenqiang;Wang, Yiqin;Cui, Wenqiang;Yuan, Shuguang;Wang, Yiqin;Loake, Verity I. P.;Loake, Gary J.
关键词：
