Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus
文献类型： 外文期刊
作者： Zhao, Yangyang 1 ; Qian, Guoliang 1 ; Ye, Yonghao 1 ; Wright, Stephen 2 ; Chen, Haotong 2 ; Shen, Yuemao 3 ; Liu, Feng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Plant Protect, Nanjing 210095, Jiangsu, Peoples R China
2.Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
3.Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Jinan 250100, Peoples R China
4.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing 210014, Jiangsu, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
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收录情况： SCI
摘要： Heterocyclic aromatic N-oxides often have potent biological activities, but the mechanism for aromatic N-oxidation is unclear. Six phenazine antibiotics were isolated from Lysobacter antibioticus OH13. A 10 gene cluster was identified for phenazine biosynthesis. Mutation of LaPhzNO1 abolished all N-oxides, while non-oxides markedly increased. LaPhzNO1 is homologous to Baeyer-Villiger flavoproteins but was shown to catazlye phenazine N-oxidation. LaPhzNO1 and LaPhzS together converted phenazine 1,6-dicarboxylic acid to 1,6-dihydroxyphenazine N5,N10-dioxide. LaPhzNO1 also catalyzed N-oxidation of 8-hydroxyquinoline.
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