文献类型： 外文期刊
作者： Wang, Kairong 1 ; Jia, Fengjing 1 ; Dang, Wen 1 ; Zhao, Yanyan 1 ; Zhu, Ranran 1 ; Sun, Mengyang 1 ; Qiu, Shuai 2 ; An, X 1 ;
作者机构： 1.Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, Sch Basic Med Sci,Key Lab Preclin Study New Drugs, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China
2.Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, Sch B
关键词： antimicrobial peptide;polybia-CP;candidiasis;antifungal;ROS production
期刊名称：JOURNAL OF PEPTIDE SCIENCE （ 影响因子：1.905； 五年影响因子：2.244 ）
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年卷期：
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收录情况： SCI
摘要： The incidence of life-threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia-CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane-active action mode. In addition, polybia-CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia-CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.
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