Enhanced Immunogenicity of Foot-and-Mouth Disease Virus-like Particles Using a Water-in-Oil-in-Water Adjuvant
文献类型： 外文期刊
作者： Zhou, Yujie 1 ; Yin, Wenzhu 2 ; Teng, Zhidong 5 ; Zhao, Yanyan 2 ; Lu, Yu 2 ; Qian, Yingjuan 1 ; Deng, Bihua 2 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China
3.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China
4.GuoTai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 225300, Peoples R China
5.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Natl Foot and Mouth Dis Reference Lab, Lanzhou 730046, Peoples R China
6.Minist Agr & Rural Affairs, Publ R&D Platform Vet Vaccines Mol Design & Formul, Nanjing 210031, Peoples R China
关键词： foot-and-mouth disease; virus-like particle; W/O/W double emulsion; adjuvant
期刊名称：VACCINES （ 影响因子：3.4； 五年影响因子：3.7 ）
ISSN：
年卷期： 2025 年 13 卷 1 期
页码：
收录情况： SCI
摘要：
Background: Foot-and-mouth disease (FMD) causes significant economic losses, prompting vaccination as a primary control strategy. Virus-like particles (VLPs) have emerged as promising candidates for FMD vaccines but require adjuvants to enhance their immunogenicity. In this study, we evaluated the immunogenicity of a VLP-based vaccine with a water-in-oil-in-water (W/O/W) emulsion adjuvant, named WT. Methods: The WT adjuvant was mixed with FMD VLPs to form the VLPs+WT vaccine. The size and stability of the vaccine were analyzed. BALB/c mice were immunized with the VLPs+WT vaccine, and immunological responses were assessed through antibody measurements, cytokine profiling, and gene expression analysis. In addition, splenic lymphocyte proliferation and signaling pathways were examined. Results: The VLPs+WT vaccine exhibited a homogeneous size of 324.60 +/- 2.30 nm and a viscosity of 8.76 mPa
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