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A 2⁃dicyanomethylene⁃3⁃cyano⁃4,5,5⁃trimethyl⁃2,5⁃dihydrofuran⁃based near⁃infrared fluorescence probe for the detection of hydrogen sulfide and imaging of living cells

文献类型: 外文期刊

作者: Zhang, Linfang 1 ; Yin, Wenzhu 2 ; Yin, Gui 1 ;

作者机构: 1.Yili Normal Univ, Sch Chem & Chem Engn, Yining 835000, Xinjiang, Peoples R China

2.Jiangsu Acad Agr Sci, Natl Res Ctr Engn & Technol Vet Biol, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China

3.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China

关键词: hydrogen sulfide; near-infrared fluorescence probe; cell imaging

期刊名称:CHINESE JOURNAL OF INORGANIC CHEMISTRY ( 影响因子:0.7; 五年影响因子:0.5 )

ISSN: 1001-4861

年卷期: 2025 年 41 卷 3 期

页码:

收录情况: SCI

摘要: Using 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) as a near-infrared fluorescent chromophore, we designed and synthesized a TCF-based fluorescent probe TCF-NS by introducing 2,4-dinitrophenyl ether as the recognized site for H2S. The probe TCF-NS displayed a rapid-response fluorescent against H2S with high sensitivity and selection but had no significant fluorescence response to other biothiols. Furthermore, TCF-NS was applied to sense H2S in living cells successfully with minimized cytotoxicity and a large Stokes shift.

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