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Cistanche deserticola polysaccharide- functionalized dendritic fibrous nano-silica- based adjuvant for H 9 N 2 oral vaccine enhance systemic and mucosal immunity in chickens

文献类型： 外文期刊

作者： He, Jin 1 ; Lu, Xuanqi 1 ; Mao, Ningning 1 ; Zhu, Tianyu 1 ; Yu, Lin 1 ; Yu, Yaming 1 ; Peng, Song 1 ; Deng, Xiangwen 1 ; Hu, Bing 1 ; Jiang, Wenming 3 ; Lu, Yu 2 ; Wang, Deyun 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China

3.China Anim Hlth & Epidemiol Ctr, Qingdao, Peoples R China

关键词： Oral vaccine; Dendritic fibrous nano-silica; Adjuvant; Mucosal and systemic immunity; cetyltrimethylammonium bromide (CTAB); triethanolamine (TEA); sodium salicylate (Nasal); tetraethoxysilane (TEOS); 3-aminopropyltriethoxysilane (APTES); 1-Ethyl-3-(3-dimethylaminopropyl); carbodiimide(EDC & sdot;HOL); N-Hydroxy succinimide (NHS); Lipopolysaccharide (LPS); phytohaemagglutinin (PHA); Cistanche deserticola polysaccharide (CDP)

期刊名称：INTERNATIONAL JOURNAL OF PHARMACEUTICS （ 影响因子：5.3； 五年影响因子：5.6 ）

ISSN： 0378-5173

年卷期： 2024 年 660 卷

页码：

收录情况： SCI

摘要： Avian influenza virus subtype H 9 N 2 has the ability to infect birds and humans, further causing significant losses to the poultry industry and even posing a great threat to human health. Oral vaccine received particular interest for preventing majority infection due to its ability to elicit both mucosal and systemic immune responses, but their development is limited by the bad gastrointestinal (GI) environment, compact epithelium and mucus barrier, and the lack of effective mucosal adjuvants. Herein, we developed the dendritic fibrous nano-silica (DFNS) grafted with Cistanche deserticola polysaccharide (CDP) nanoparticles (CDP-DFNS) as an adjuvant for H 9 N 2 vaccine. Encouragingly, CDP-DFNS facilitated the proliferation of T and B cells, and further induced the activation of T lymphocytes i n vitro . Moreover, CDP-DFNS/H9N2 significantly promoted the antigen-specific antibodies levels in serum and intestinal mucosal of chickens, indicating the good ability to elicit both systemic and mucosal immunity. Additional, CDP-DFNS facilitate the activation of CD4 + and CD8 + T cells both in spleen and intestinal mucosal, and the indexes of immune organs. This study suggested that CDP-DFNS may be a new avenue for development of oral vaccine against pathogens that are transmitted via mucosal route.

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