Dietary litchi pulp polysaccharides could enhance immunomodulatory and antioxidant effects in mice
文献类型: 外文期刊
作者: Huang, Fei 1 ; Zhang, Ruifen 1 ; Liu, Yang 1 ; Xiao, Juan 1 ; Liu, Lei 1 ; Wei, Zhencheng 1 ; Yi, Yang; Zhang, Mingwei 2 ;
作者机构: 1.Guangdong Acad Agr Sci, Guangdong Key Lab Agr Prod Proc, Sericultural & Agri Food Res Inst, Key Lab Funct Foods,Minist Agr, Guangzhou 510610, Guangdong, Peoples R China
2.Guan
关键词: Litchi pulp polysaccharides;Immunomodulatory activity;Antioxidant activity
期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:6.953; 五年影响因子:6.737 )
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收录情况: SCI
摘要: The purpose of this study was, to investigate the immunomodulatory and antioxidant activities of litchi pulp polysaccharides (LP) in cyclophosphamide (Cy)-induced mice. The administration of LP (50, 100 and 200 mg/kg/d) remarkably enhanced mesenteric lymph node cells proliferation and serum IgA. Moreover, IL-6, TNF-alpha, IgG and IgM levels in serum were significantly improved in a dose-dependent manner with LP treatment. Dietary LP induced systemic immune responses including stimulating the proliferation of splenocytes, balancing the ratio of spleen lymphocyte subsets, up-regulating the thymus and spleen indices. Thus, we speculate litchi polysaccharides would express their systemic immunomodulatory effects by triggering the intestinal mucosal immunity. Likewise, LP also significantly increased total antioxidant capacity, as well as superoxidase dismutase and glutathione peroxidase activity, while decreasing malondialdehyde levels in the serum and liver. The immunomodulatory activity of LP was accompanied with its antioxidant activity, which might be related with its structure and prebiotic effect. This is a novel study on the relationship between the immunomodulatory and antioxidant activities of litchi polysaccharides. (C) 2016 Published by Elsevier B.V.
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