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Anti-endotoxin and anti-inflammatory effects of Chinese herbal medicinal alkaloid ingredients in vivo

文献类型： 外文期刊

作者： Hu, Yiyi 1 ; Mao, Aihua 1 ; Yu, Zhengyu 1 ; He, Kongwang 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Natl Ctr Engn Res Vet Bioprod, Inst Vet Med, Key Lab Vet Biol Engn & Technol,Minist Agr, Nanjing, Jiangsu, Peoples R China

2.Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

关键词： Endotoxin;Inflammation;Alkaloids;LPS

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN：

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收录情况： SCI

摘要： The aim of the research was to investigate the anti-endotoxin and anti-inflammatory effects of sinomenine, fangchinoline, stachydrine, chuanxionggzine, oxymartrine, and evodiamine alkaloids commonly found in Chinese herbal medicines. In an endotoxin (LPS) control group, each mouse was challenged with 1 mg LPS/kg by intraperitoneal (IP) injection. In high-, middle- and low-dose alkaloid groups, mice were initially challenged with 1 mg LPS/kg by IP injection and, 3 h later, dosed intramuscularly (IM) with one of the six alkaloids at one of three levels (1, 5, or 10 mg/kg body weight). In the drug control group, mice were dosed IM with 10 mg/kg body weight of a given alkaloid; mice in a naive control group were administered the same volume of normal saline. The results revealed the six alkaloids could reduce the incidence/severity of LPS- induced toxicities, e.g., body temperature elevation, weight loss, systemic inflammation, multiple organ dysfunction. Taken together, the data suggested to us that these alkaloids might effectively regulate inflammatory responses and have a potential to be used in anti-endotoxin therapies. (C) 2016 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]Protective effects of sinomenine against LPS-induced inflammation in piglets. Yang, Haifeng,Jiang, Chunmao,Chen, Xiaolan,He, Kongwang,Hu, Yiyi.

[2]Chinese herbal medicinal ingredients affect secretion of NO, IL-10, ICAM-1 and IL-2 by endothelial cells. Hu, Yiyi,He, Kongwang,Zhu, Haodan,Hu, Yiyi,He, Kongwang,Zhu, Haodan.

[3]苏钟猪TLR4多态性及编码区C1027A功能分析. 刘筱,方晓敏,邹晓龙,赵芳,任守文. 2012

[4]脂多糖对体外培养猪颗粒细胞增殖、凋亡和雌二醇分泌的影响. 果双双,李辉,施振旦,马卫明. 2016

[5]Breed-linked polymorphisms of porcine toll-like receptor 2 (TLR2) and TLR4 and the primary investigation on their relationship with prevention against Mycoplasma pneumoniae and bacterial LPS challenge. Fang, Xiaomin,Liu, Xiao,Meng, Cui,Fu, Yanfeng,Wang, Xuemin,Li, Bixia,Tu, Feng,Zhao, Fang,Ren, Shouwen.

[6]Six Alkaloids Inhibit Secretion of IL-1 alpha, TXB2, ET-1 and E-selectin in LPS-induced Endothelial Cells. Hu, Yi-Yi,He, Kong-Wang,Guo, Rong-li. 2012

[7]Expression and Purification of a Functional Porcine Soluble Triggering Receptor Expressed on Myeloid Cells 1. Li, Hui,Yan, Leyan,Meng, Chunhua,Shi, Zhendan,Guo, Shuangshuang,Hu, Yiyi,He, Kongwang.

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