文献类型： 外文期刊
作者： Fu, Shuna 1 ; Wang, Fan 1 ; Li, Hongyu 1 ; Bao, Yixuan 1 ; Yang, Yu 1 ; Shen, Huifang 2 ; Lin, Birun; Zhou, Guangxiong 1 ;
作者机构： 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Plant Protect, Key Lab New Tech Plant Protect Guangdong, Guangzhou, Guangdong, Peoples R China;
关键词： Streptomycete;secondary metabolites;dipeptide;streptomyceamide C;piperidinedione
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： A new secondary metabolite, (2S,3R)-l-threonine, N-[3-(formylamino)-2-hydroxybenzoyl]-ethyl ester (streptomyceamide C, 1), together with four known compounds 1, 4-dimethyl-3-isopropyl-2,5-piperidinedione (2), cyclo-((S)-Pro-8- hydroxy-(R)-Ile (3), cyclo-((S)-Pro-(R)-Leu (4), and seco-((S)-Pro-(R)-Val) (5), were isolated from the EtOH extract of the fermented mycelium of the marine-derived streptomycete strain H74-21, which was isolated from sea sediment in a mangrove site. The structure of the new compound was established on the basis of its spectroscopic data, including 1D and 2D NMR, HR-TOF-MS. Their antifungal activities against Candida albicans and cytotoxicities against human breast adenocarcinoma cell line MCF-7, human glioblastoma cell line SF-268 and human lung cancer cell line NCI-H460 were tested. Compounds 1 only displayed cytotoxicity against human breast adenocarcinoma cell line MCF-7 with the IC50 value of 27.0g/mL. However, compounds 1-5 do not show antifungal activities at the test concentration of 1mg/mL, and 2-5 have no cytotoxicities at the test concentration of 50g/mL.
- 相关文献
作者其他论文 更多>>
-
Long- and short-term dietary β-glucan improves intestinal health and disease resistance in pearl gentian grouper (Epinephelus lanceolatus♂ x Epinephelus fuscoguttatus♀)
作者：Wang, Fan;Wang, Zhiwen;Lu, Yishan;Wang, Fan;Wang, Fan;Wang, Zhiwen;Cao, Junming;Lu, Yishan;Cao, Junming
关键词：beta-Glucan; Administration period; Intestinal health; Fish
-
Response signatures of intestinal microbiota and gene transcription of the pearl gentian grouper to Vibrio harveyi infection
作者：Wang, Fan;Wang, Zhiwen;Lu, Yishan;Wang, Fan;Xu, Jia;Wang, Fan;Wang, Zhiwen;Lu, Yishan;Cao, Junming;Cao, Junming;Lu, Yishan
关键词：Transcriptome; Gut microbiotas; Vibrio harveyi; Grouper
-
Dickeya fangzhongdai was prevalent and caused taro soft rot when coexisting with the Pectobacterium complex, with a preference for Araceae plants
作者：Zhang, Jingxin;Sun, Dayuan;Shen, Huifang;Pu, Xiaoming;Liu, Pingping;Lin, Birun;Yang, Qiyun;Zhang, Jingxin;Sun, Dayuan;Shen, Huifang;Pu, Xiaoming;Liu, Pingping;Lin, Birun;Yang, Qiyun;Zhang, Jingxin;Sun, Dayuan;Shen, Huifang;Pu, Xiaoming;Liu, Pingping;Lin, Birun;Yang, Qiyun
关键词：Dickeya fangzhongdai; Pectobacterium species complex; coinfection; virulence difference; genomic comparison
-
Effects of chlorantraniliprole on the development, fecundity and prey consumption of a non-specific predator, Rhynocoris fuscipes (Hemiptera: Reduviidae)
作者：Liu, Pingping;Lin, Birun;Shen, Huifang;Zhang, Jingxin;Pu, Xiaoming;Sun, Dayuan;Yang, Qiyun;Deng, Haibin;Chen, Zepeng
关键词：Reduviid bug; Rhynocoris fuscipes; Transplant treatment; Chlorantraniliprole; Agrotis ipsilon
-
Integrated transcriptome and proteome analyses unravel a series of early defence responses in Sarcandra glabra against Colletotrichum gloeosporioides
作者：Jiang, Ni;Lin, Birun;Jiang, Ni;Song, Lisha;Tan, Guiyu;Zhang, Zhanjiang;Lin, Birun;Yu, Kai;Yu, Kai
关键词：antioxidant enzyme; Colletotrichum gloeosporioides; correlation analysis; defence mechanism; photosynthesis; proteome; Sarcandra glabra; transcriptome
-
Efficacy of transplant insecticides against black cutworm Agrotis ipsilon (Lepidoptera: Noctuidae) in tobacco
作者：Liu, Pingping;Zhang, Jingxin;Shen, Huifang;Yang, Qiyun;Pu, Xiaoming;Sun, Dayuan;Lin, Birun;Ge, Baiyi
关键词：Chlorantraniliprole; Underground pests; Anthranilic diamides; Systematic application; IPM; A; ipsilon; Black cutworm
-
Genomic Comparisons and Phenotypic Diversity of Dickeya zeae Strains Causing Bacterial Soft Rot of Banana in China
作者：Zhang, Jingxin;Shen, Huifang;Sun, Dayuan;Pu, Xiaoming;Lin, Birun;Yang, Qiyun;Arif, Mohammad;Hu, John
关键词：Dickeya zeae; bacterial soft rot of banana; genomic comparisons; phenotypic diversity; pathogenicity
