文献类型： 外文期刊
作者： Fu, Shuna 1 ; Wang, Fan 1 ; Li, Hongyu 1 ; Bao, Yixuan 1 ; Yang, Yu 1 ; Shen, Huifang 2 ; Lin, Birun; Zhou, Guangxiong 1 ;
作者机构： 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Plant Protect, Key Lab New Tech Plant Protect Guangdong, Guangzhou, Guangdong, Peoples R China;
关键词： Streptomycete;secondary metabolites;dipeptide;streptomyceamide C;piperidinedione
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
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收录情况： SCI
摘要： A new secondary metabolite, (2S,3R)-l-threonine, N-[3-(formylamino)-2-hydroxybenzoyl]-ethyl ester (streptomyceamide C, 1), together with four known compounds 1, 4-dimethyl-3-isopropyl-2,5-piperidinedione (2), cyclo-((S)-Pro-8- hydroxy-(R)-Ile (3), cyclo-((S)-Pro-(R)-Leu (4), and seco-((S)-Pro-(R)-Val) (5), were isolated from the EtOH extract of the fermented mycelium of the marine-derived streptomycete strain H74-21, which was isolated from sea sediment in a mangrove site. The structure of the new compound was established on the basis of its spectroscopic data, including 1D and 2D NMR, HR-TOF-MS. Their antifungal activities against Candida albicans and cytotoxicities against human breast adenocarcinoma cell line MCF-7, human glioblastoma cell line SF-268 and human lung cancer cell line NCI-H460 were tested. Compounds 1 only displayed cytotoxicity against human breast adenocarcinoma cell line MCF-7 with the IC50 value of 27.0g/mL. However, compounds 1-5 do not show antifungal activities at the test concentration of 1mg/mL, and 2-5 have no cytotoxicities at the test concentration of 50g/mL.
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