广东省农业科学院机构知识库

Exploring the molecular mechanism of acute heat stress exposure in broiler chickens using gene expression profiling

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文献类型：外文期刊

作者： Luo, Q. B. ¹ ; Song, X. Y. ² ; Ji, C. L. ³ ; Zhang, X. Q. ¹ ; Zhang, D. X. ¹ ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

2.South China Agr Univ, Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

3.Guangdong Wens Food Grp Ltd Co, Xinxing 527439, Guangdong, Peoples R China

关键词： Chicken;Heat-stress response;Gene expression;Gene module

期刊名称：GENE （影响因子：3.688；五年影响因子：3.329 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： The process of heat regulation is complex and its exact molecular mechanism is not fully understood. In this study, to investigate the global gene regulation response to acute heat exposure, gene microarrays were exploited to analyze the effects of heat stress on three tissues (brain, liver, leg muscle) of the yellow broiler chicken (Gallus gallus). We detected 166 differentially expressed genes (DEGs) in the brain, 219 in the leg muscle and 317 in the liver. Six of these genes were differentially expressed in all three tissues and were validated by qRT-PCR, and included heat shock protein genes (HSPH1, HSP25), apoptosis-related genes (RB1CC1;BAG3), a cell proliferation and differentiation-related gene (ID1) and the hunger and energy metabolism related gene (PDK). All these genes might be important factors in chickens suffering from heat stress. We constructed gene co-expression networks using the DEGs of the brain, leg muscle and liver and two, four and two gene co-expression modules were identified in these tissues, respectively. Functional enrichment of these gene modules revealed that various functional clusters were related to the effects of heat stress, including those for cytoskeleton, extracellular space, ion binding and energy metabolism. We concluded that these genes and functional clusters might be important factors in chickens under acute heat stress. Further in-depth research on the newly discovered heat-related genes and functional clusters is required to fully understand their molecular functions in thermoregulation. (C) 2014 Elsevier B.V. All rights reserved.

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关键词：

Exploring the molecular mechanism of acute heat stress exposure in broiler chickens using gene expression profiling

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