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The evolution mechanism of intron length

文献类型： 外文期刊

作者： Zhang, Qiang 1 ; Li, Hong 1 ; Zhao, Xiao-qing 2 ; Xue, Hui 3 ; Zheng, Yan 1 ; Meng, Hu 1 ; Jia, Yun 1 ; Bo, Su-ling 1 ;

作者机构： 1.Inner Mongolia Univ, Sch Phys Sci & Technol, Lab Theoret Biophys, Hohhot 010021, Peoples R China

2.Inner Mongolia Acad Agr & Anim Husb Sci, Biotechnol Res Ctr, Hohhot 010021, Peoples R China

3.Inner Mongolia Univ, Foreign Languages Coll, Hohhot 010021, Peoples R China

关键词： Ribosomal protein genes;mRNA;Introns;Local matched;Optimal matched segments

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

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收录情况： SCI

摘要： Within two years of their discovery in 1977, introns were found to have a positive effect on gene expression. Our result shows that introns can achieve gene expression and regulation through interaction with corresponding mRNA sequences. On the base of Smith-Waterman method, local comparing helps us get the optimal matched segments between intron sequences and mRNA sequences. Studying the distribution regulation of the optimal matching region on intron sequences of ribosomal protein genes about 27 species, we find that the intron length evolution processes beginning from 5' end to 3' end and increasing one by one structural unit, which comes up with a possible mechanism for the intron length evolution. The intron of structure units is conservative with about 60 bp length, but the length of linker sequence between structure units changes a lot. Interestingly, distributions of the length and matching rate of optimal matched segments are consistent with sequence features of miRNA and siRNA. These results indicate that the interaction between intron sequences and mRNA sequences is a kind of functional RNA-RNA interaction. Meanwhile, the two kinds of sequences above are co-evolved and interactive to play their functions. (C) 2016 Elsevier Inc. All rights reserved.

  • 相关文献

[1]Analysis on the preference for sequence matching between mRNA sequences and the corresponding introns in ribosomal protein genes. Zhang, Qiang,Li, Hong,Zheng, Yan,Meng, Hu,Jia, Yun,Bo, Sulin,Zhao, Xiaoqing,Xue, Hui.

[2]Distribution bias of the sequence matching between exons and introns in exon joint and EJC binding region in C. elegans. Zhang, Qiang,Li, Hong,Zheng, Yan,Zhou, Deliang,Zhao, Xiaoqing.

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